Search for dissertations about: "phenytoin"

Showing result 1 - 5 of 13 swedish dissertations containing the word phenytoin.

  2. 1. Zinc in cerebrospinal fluid and serum in some neurological diseases

    Author : Ragnar Palm; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; zinc; copper; serum; cerebrospinal fluid; albumin; multiple sclerosis; epilepsy; phenytoin; blood brain barrier damage; subarachnoid haemorrhage.;

    Abstract : The trace elements zinc and copper are essential components of many enzymes, some of which are of importance for the development and function of the central nervous system. Deficiency of the metals has been shown to lead to malformations and to the loss of myelin in animals. READ MORE

  4. 2. Mechanistic studies on skeletal malformations caused by phenytoin, vasodilating drugs and selenium

    Author : Kiki Danielson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE

  5. 3. Teratogenicity as a consequence of drug-induced embryonic cardiac arrhythmia : Common mechanism for almokalant, sotalol, cisapride, and phenytoin via inhibition of IKr

    Author : Anna-Carin Sköld; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; IKr; delayed rectifying K channel; embryonic cardiac arrhythmia; teratogenicity; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Toxicology; toxikologi;

    Abstract : During the last years, drugs that prolong the repolarisation phase of the myocardial action potential, due to inhibition of the rapid component of the delayed-rectifying potassium channel (IKr) have been in focus. In addition to arrhythmogenic potential, selective Ikr-blockers have also been shown to be embryotoxic and teratogenic in animal studies. READ MORE

  6. 4. Cytochrome P450 2C9, 2C19 and 2D6 genetic polymorphisms : evaluation of genotyping as a tool for individualised treatment

    Author : Maria Gabriella Scordo; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Drug metabolism; CYP2C9; CYP2C19; CYP2D6; genotyping; polymorphism; risperidone; warfarin; fluoxetine; phenytoin; extrapyramidal side-effects;

    Abstract : Recent advances in the understanding of drug metabolism and the molecular biology of CYPs have generated great expectations regarding the use of pharmacogenetic testing as a tool to individualize drug treatment. The individual pharmacogenetic constitution might in principle predict the response to drugs, hormones and toxins. READ MORE

  7. 5. Role of the hERG-channel in arrhythmia and teratogenicity : studies in animal models and the human embryonic heart

    Author : Christian Danielsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Drugs that inhibit cardiac repolarization are associated with potentially life threatening side effects in the form of ventricular arrhythmias in humans. Animal studies show that this mechanism also is relevant for the embryo, and that the circulatory depression results in hypoxia with embryotoxicity in the form of malformations and death as a consequence. READ MORE