Search for dissertations about: "physical diseases"

Showing result 1 - 5 of 369 swedish dissertations containing the words physical diseases.

2. 1. Modeling DNA Damage

   Author : Patric Schyman; Aatto Laaksonen; Sason Shaik; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; DNA; Ionizing radiation; DNA radicals; Strand break; Hydrogen abstraction; Density Functional Theory; Car-Parrinello Molecular Dynamics; QM MM; Physical chemistry; Fysikalisk kemi; Physical Chemistry; fysikalisk kemi;

   Abstract : In this thesis methods of computational chemistry have been used to examine DNA damaging processes initiated by ionizing radiation, free radicals, or Low-Energy Electrons (LEE). The computational chemistry method based on quantum mechanics that has been mainly used here is the Density Functional Theory (DFT). READ MORE

4. 2. Modeling of biomembranes: from computational toxicology to simulations of neurodegenerative diseases

   Author : Inna Ermilova; Alexander Lyubartsev; Marta Pasenkiewicz-Gierula; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; biomembranes; lipid bilayers; Alzheimer s disease; Parkinson disease; computational toxicology; passive diffusion; hydroxylated polybrominated diphenyl ethers; omega-3; omega-6; amyloid beta peptide; molecular dynamics simulations; SLipids force field; fysikalisk kemi; Physical Chemistry;

   Abstract : It was known from the middle of the last century that a cell-membrane is a lipid bilayer. Since that time a large number of experimental studies has been done in order to see how a certain molecule can penetrate through a membrane. READ MORE

5. 3. Bone mass and physical activity

   Author : Anna Nordström; Tommy Olsson; Peter Nordström; Heather McKay; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; physical activity; peak bone mineral density; males; fractures; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; medicin; Medicine;

   Abstract : Abstract Weak and osteoporotic bones in old age are an increasing cause of mortality and painful physical impairment of the elderly, especially in the western world. Bone mineral accrual during childhood and adolescence is thought to play a vital role in preventing osteoporosis. READ MORE

6. 4. Biological membrane interfaces involved in diseases : a biophysical study

   Author : Fredrick Lindström; Gerhard Gröbner; Dick Sandström; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Solid-state NMR; DSC; Amyloid-beta peptide; Nociceptin; DMPC; DMPG; DDAB; peptide-lipid interaction; branched-chain fatty acid.; Biophysical chemistry; Biofysikalisk kemi;

   Abstract : Interactions between peptides and biological lipid membranes play a crucial role in many cellular processes such as in the mechanism behind Alzheimer’s disease where amyloid-beta peptide (Abeta)is thought to be a key component. The initial step of binding between a surface active peptide and its target membrane or membrane receptor can involve a non specific electrostatic association where positively charged amino acid residues and a negatively charged membrane surface interact. READ MORE

7. 5. FACING THE CHALLENGE OF SKIN PENETRATION - A STUDY ON LIPIDIC LIQUID CRYSTALLINE PHASES FOR DERMAL DRUG DELIVERY

   Author : Hanne Evenbratt; Chalmers tekniska högskola; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; 5-diol; liquid crystalline phases; N-Methyl-2-pyrrolidone; pentane-1; glyceryl monooleat; propylene glycol; dermal drug delivery; glyceryl monooleyl ether; cubic phase; reversed hexagonal phase;

   Abstract : The skin is a barrier which protects us against daily attacks of foreign substances. From a pharmaceutical perspective it is also an interesting delivery route with its large surface and possibility to reach the blood stream circumventing first passage metabolism. With the varied size, structure etc. READ MORE