Search for dissertations about: "pk11195"
Showing result 1 - 5 of 9 swedish dissertations containing the word pk11195.
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1. 11C Molecular Imaging in Focal Epilepsy
Abstract : Epilepsy is a common neurological disease affecting 6 million people in Europe. Early prevention and accurate diagnosis and treatment are of importance to obtain seizure freedom. In this thesis new applications of carbon-11-labelled tracers in PET and autoradiographic studies were explored in focal epilepsy. READ MORE
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2. Transition Metal Mediated Transformations of Carboranes
Abstract : This thesis describes the use of copper and palladium to mediate transformations of carboranes, especially p-carborane.1-(1-p-carboranyl)-N-methyl-N-(2-butyl)-3-isoquinolinecarboxamide, a carborane containing analogue of the peripheral benzodiazepine receptor (PBR) ligand PK11195, has been synthesised. READ MORE
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3. Abdominal Aortic Aneurysm : Molecular Imaging Studies of Pathophysiology
Abstract : The pathological process behind abdominal aortic aneurysm (AAA) formation is poorly understood and difficult to study. The aim of the thesis was to study the pathophysiology of AAA formation with positron emission tomography (PET) technology, a molecular imaging technique, allowing in vivo studies of pathophysiological changes. READ MORE
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4. Aryltriflates and (11C)Carbon monoxide in the synthesis of 11C-carbonyl compounds. Synthesis of 11C-PK11195, analogues and some other amides
Abstract : .... READ MORE
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5. [11C]Carbon Monoxide and Aryl Triflates in Palladium-Mediated Carbonylation Reactions : Synthetic approaches to [11C]Carbonyl Compounds and [11C]Amines
Abstract : The usefulness of low concentrations (typically 10 to 100 µM) of [11C]carbon monoxide and aryl triflates as substrates in 11C-carbonylation using different nucleophiles in the presence of lithium bromide was investigated. The reactions were performed in a micro autoclave of 200 µL volume and catalysed (mediated) by palladium(0). READ MORE