Search for dissertations about: "plasmid DNA"

Showing result 1 - 5 of 116 swedish dissertations containing the words plasmid DNA.

  2. 1. Development of benzoquinoquinoxaline derivatives as triplex-specific probes : Recognition of DNA structures at repeats sequences

    Author : Helen Bergquist; Rula Zain; Keith Fox; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Triplex; H-DNA; BQQ; BQQ-OP; BQQ-Bodipy; triplet repeat; DNA; non-B-DNA; pkd1; frataxin; Friedreich s ataxia; Molecular biology; Molekylärbiologi; Molecular Biology; molekylärbiologi;

    Abstract : Repeat sequences are associated with several human diseases, such as Friedreich’s ataxia, polycystic kidney disease and cancer. These sequences can form non-B-DNA structures, including triplex (H-DNA) DNA, and are associated with genomic instability and altered gene expression. READ MORE

  4. 2. Novel Chromatography Matrices for Fast Isolation of Plasmid DNA

    Author : Peter Tiainen; Tillämpad biokemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biokemisk teknik; Polymer technology; biopolymers; Polymerteknik; Biotechnology; Bioteknik; Biochemical technology; Plasmid recovery.; Composite materials; Kompositmaterial; Coating and surface treatment; Skikt och ytbehandling; Superporous agarose; Silica fibres; Plasmid purification; Anion-exchange matrices;

    Abstract : As new therapeutic areas in which genetic material is employed, i.e. gene therapy and DNA vaccination, are expanding, a substantial increase in the demand for gene vectors, e.g. READ MORE

  5. 3. Specific Precipitation of Biomolecules Using Synthetic Polymers

    Author : Per-Olof Wahlund; Bioteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Biotechnology; Polymerteknik; RNA; plasmid DNA; DNA; polyelectrolyte complexes; synthetic polymers; precipitation; affinity precipotation; Bioteknik; Polymer technology; biopolymers;

    Abstract : Purification is a very important stage in biotechnological processes. The traditionally used precipitation techniques are generally nonspecific and thus one or more chromatographic steps are normally required. There is thus a need for new approaches to improve existing techniques. READ MORE

  6. 4. Primary Sjögren's Syndrome: Studies of DNA damage responses and autoantibodies

    Author : Gunnel Henriksson; Malmö Klinisk mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; autoantibodies; 18 ; t 14; cell cycle; p53; DNA-PK; DNA-binding protein; hypermutation; Sjögren s syndrome; DNA damage; anti-CD4 antibodies; Microbiology; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Abstract : Primary Sjögren’s syndrome (SS) is a chronic autoimmune disease of unknown etiology. The disease primarily involves lachrymal and salivary glands, leading to dryness of the eyes and mouth, but a wide spectrum of exocrine and non-exocrine disease manifestations may be seen. READ MORE

  7. 5. DNA vaccines and bacterial DNA in immunity

    Author : Lisa Charlotta Bandholtz; Karolinska Institutet; Karolinska Institutet; []
    Keywords : DNA vaccine; CpG DNA; antimicrobial peptides C. pneumoniae; Shigella spp;

    Abstract : This thesis describes DNA-based vaccination and the importance of bacterial DNA in different immunological perspectives. Intranasal (i.n.) DNA vaccination utilizing a plasmid encoding the chlamydial heat shock protein 60 (p-hsp-60) generated lower bacterial burden and reduced pathology in the lungs of mice after subsequent infection with C. READ MORE