Search for dissertations about: "platelet-derived growth factor-B"

Showing result 1 - 5 of 21 swedish dissertations containing the words platelet-derived growth factor-B.

  2. 1. Transcriptional regulation of the platelet-derived growth factor B gene

    Author : Stephen J. Miller; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biology; Biologi; Biology; Biologi; Developmental Biology; miljömedicinsk utvecklingsbiologi;

    Abstract : The Platelet-Derived Growth Factor B (PDGF-B) gene product is an important protein during development and adult life, as well as being associated with the development of many tumour types. It has been ascribed roles in many normal and pathological processes including angiogenesis, tissue repair, atherosclerosis and cytotrophoblast proliferation. READ MORE

  4. 2. Pericyte recruitment and functions in vivo. Studies of platelet-derived growth factor-B deficient embryos

    Author : Mats Hellström; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mouse; gene targeting; platelet-derived growth factor; pericyte; vascular smooth muscle; angiogenesis;

    Abstract : A functional vascular system is essential for tissue growth and maintenance, and the circulatory system is therefore the first operational organ of the vertebrate embryo. In conditions of pathological tissue growth, such as tumors, formation of new blood vessels is also required, and it is anticipated that prevention of blood vessel development in those settings might ameliorate the disease progress. READ MORE

  5. 3. Role of platelet-derived growth factor B in cholesterol and glucose metabolism

    Author : Tian Li; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Platelet-derived growth factor (PDGFB) is a critical molecule for recruiting pericytes. Due to the fundamental role of the pericytes in angiogenesis and vascular stability, PDGFB knockout mice die perinatally from severe hemorrhage and edema. READ MORE

  6. 4. Transcriptional Regulation of the Platelet-Derived Growth Factor B-receptor by p53 Family Members

    Author : Daniel Wetterskog; Göteborgs universitet; []
    Keywords : ;

    Abstract : Aims: The platelet-derived growth factor ?-receptor (PDGFRB) is critically involved in embryonic development and has a role in many diseases. In cells, signaling through PDGFRB affects growth, migration and death. READ MORE

  7. 5. Role of extracellular retention of platelet-derived growth factor-B. Functions in development and disease

    Author : Per Lindblom; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; pericyte; cancer; fibrosis; ECM; HSPG; cell retention; endothelial;

    Abstract : During development, the cell secretes growth and differentiation factors (GDFs) to the surrounding microenvironment. These factors are often key regulators of organogenesis and embryogenesis. Several GDFs carry sequences that mediate specific interaction with molecules of the extracellular matrix (ECM) that surrounds the cell. READ MORE