Search for dissertations about: "polyamine uptake"

Found 5 swedish dissertations containing the words polyamine uptake.

2. 1. On the binding of growth-promoting polyamines to proteoglycans: Implications for growth-regulation and polycation-mediated gene transfer

   Author : Mattias Belting; Institutionen för experimentell medicinsk vetenskap; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; cationic lipid.; gene transfer; gene therapy; cell growth; polyamine transport; spermine; polyamine; growth-inhibition; heparan sulphate; dermatan sulphate; Proteoglycan; glycosaminoglycan; cytogenetics; Genetik; cytogenetik;

   Abstract : Initial investigations were directed at studying the interaction between polyamines and various glycosaminoglycans (GAGs). The polyamine spermine displayed binding to dermatan sulphate (DS) and heparan sulphate (HS) with similar (Kd, 3.9 x 10-4 M) and higher (Kd, 0.37 x 10-6 M) affinity, respectively, than to DNA. READ MORE

4. 2. Effects of polyamine pool manipulation on genes expressed during the cell cycle

   Author : Pia Berntsson; Biologiska institutionen; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Animal physiology; cyclin A; ODC; MCF-7; mitotic shake off; DENSPM; CHO; cDNA microarray; cell cycle; spermine; Djurfysiologi; AdoMetDC; 2D gel electrophoresis; polyamines; spermidine; putrescine;

   Abstract : The polyamines - putrescine, spermidine and spermine - are polycations found within cells. They have been shown to be essential for optimal cell proliferation and cell survival. Cells maintain their polyamine levels in a well-regulated system involving biosynthesis, catabolism and uptake/excretion. READ MORE

5. 3. REGULATED UPTAKE OF BIOPOLYMERS Role of cell surface proteoglycans Implications for drug and gene delivery

   Author : Staffan Sandgren; Bröstcancer-genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Cytology; oncology; proliferation; differentiation; Medicine human and vertebrates ; growth factor; cancer; drug delivery; gene therapy; LL-37; HIV-Tat; cell penetrating peptides; polyamines; heparan sulfate; onkologi; Cytologi; cancerology; internalization; proteoglycans;

   Abstract : Cells continuously export, import, and recycle molecules over the plasma membrane. Internalization, i.e. cellular import of extracellular material, is a fundamental process, which provides cells with nutrients and enables the immune cells of higher organisms to remove debris, sample their surroundings for antigens and to fight microbes. READ MORE

6. 4. Mechanistic Studies On the Role of Polyamines and Microvesicles in Tumor Growth and Hypoxia-mediated Angiogenesis

   Author : Katrin Svensson; Bröstcancer-genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioblastoma; angiogenesis; hypoxia; microvesicles; exosomes; polyamines; tissue factor; coagulation;

   Abstract : Solid tumors are composed of cancer cells, as well as resident or infiltrating non-malignant cells that contribute to the malignant state in an ecosystem generally accepted as the tumor microenvironment. Microenvironmental tumor hypoxia is the foremost leading cause of angiogenesis, i.e. READ MORE

7. 5. On the Role of Polyamines and Microvesicles in Tumour Development. Regulation by Hypoxia and Implications for Therapeutic Intervention of Cancer

   Author : Johanna Welch; Bröstcancer-genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; heparan sulphate proteoglycans; cancer; hypoxia; polyamines; microvesicles; anti-angiogenic therapy; angiogenesis;

   Abstract : Novel strategies for specific tumour cell targeting are necessary in order to improve survival rates and to reduce side effects of current therapies in cancer patients. Hypoxia is a hallmark of solid tumours and one of the major driving forces for tumour progression. READ MORE