Search for dissertations about: "polyclonal activation"

Showing result 1 - 5 of 41 swedish dissertations containing the words polyclonal activation.

  2. 1. Heavy Metal Superantigen : Genetic Regulation of Lymphocyte Activation by HgC12

    Author : Yun Jiang; Peter Mathieson; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; immunologi; Immunology;

    Abstract : Injections of subtoxic doses of HgCl2 (mercuric chloride) cause a systemic autoimmune disease in genetically predisposed rats and mice. My work was designed to elucidate how HgCl2 induces lymphocyte activation and how the response to HgCl2 is regulated in susceptible and resistant strains. READ MORE

  4. 2. Perspectives on the Biological Role of Human Prostasomes

    Author : Lena Carlsson; Outi Hovatta; Uppsala universitet; []
    Keywords : Medical sciences; Prostasomes; cryopreservation; human spermatozoa; sperm motility; anti- prostasome antibodies; PC-3 cells; Bacillus megaterium; antibacterial; antisperm antibodies; complement activation; sperm agglutination; infertility; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Clinical Chemistry; klinisk kemi;

    Abstract : Prostasomes are extracellularly occurring organelles which are secreted in human semen by the prostate gland. Prostasomes have several known biological activities, but their physiological function is still unclear. In this thesis some new aspects were studied on the biological role of the prostasomes. READ MORE

  5. 3. Heavy metal-induced activation of the murine immune system and autoimmunity : a comparative study of mercury and silver

    Author : Uno Johansson; Klas Nordlind; Östergötlands Läns Landsting; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : The activation and proliferation ofT- and B-cells induced by treatment with mercuric chloride (HgC12) or silver·nitrate (AgN03) was studied in mouse strains genetically susceptible (SJL, A. SW, A.TH, BALE/C) or resistant (A.TL, BALB. READ MORE

  6. 4. Immune activation during HIV-1 infection : implication for B cell dysfunctions and therapy monitoring

    Author : Angelo De Milito; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV; B cell memory; hypergammaglobulinemia; immune activation; Fas-FasL; CD27-CD70;

    Abstract : Aberrant activation of cells of the immune system plays a major role in the pathogenesis of HIV infection. The major aims of the thesis were: (a) to measure the effects of current antiretroviral therapy on immune activation through the analysis of soluble activation markers; (b) to evaluate the extent of T and B cell immune activation in relation to immunological and virological parameters; (c) to analyse the T-B cell molecular pathway leading to hyperactivation of B cells and loss of B cell function. READ MORE

  7. 5. Mechanisms influencing activation and survival of normal and malignant lymphoid cells in the testis

    Author : Mikael von Euler; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Acute lymphoblastic leukaemia; testis; cytokines; IL-1; TGFbeta;

    Abstract : Acute lymphoblastic leukaemia (ALL) is the most common childhood malignancy and the testis is the third most common site of relapse after treatment. Testicular function is regulated by pituitary hormones, but the testicular microenvironment is also locally regulated through cell-cell interactions and by paracrine factors. READ MORE