Search for dissertations about: "polyplex"

Found 3 swedish dissertations containing the word polyplex.

  2. 1. Dendrimer-mediated gene delivery: Effect of polymer structure on cellular response

    Author : Kristina Fant; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; gene therapy; DNA condensation; cationic polymers; toxicity; non-viral vector; drug delivery; polyplex; PAMAM dendrimers;

    Abstract : The delivery of nucleic acids to cells, in vitro and in vivo, is becoming a realistic approach for intervention with gene expression at a molecular level. It can be used to repair malfunctioning genes or to introduce new functionalities, with the most important application being clinical treatment of human diseases. READ MORE

  4. 2. Chitosan Polyplexes as Non-Viral Gene Delivery Systems : Structure-Property Relationships and In Vivo Efficiency

    Author : Magnus Köping-Höggård; Per Artursson; Jean-Paul Behr; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; gene therapy; gene delivery; non-viral; polyplex; chitosan; chitosan oligomers; polyethylenimine; plasmid DNA; lung; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Abstract : The subject of this thesis was to develop and optimize delivery systems for plasmid DNA (pDNA) based on biocompatible polymers, in particular chitosan, suitable for non-viral gene therapy. At the onset of this thesis, studies had reported conflicting results on the efficiency of chitosan-based gene delivery systems. READ MORE

  5. 3. Transplantation of mesenchymal stem cells and injections of microRNA as therapeutics for nervous system repair

    Author : Mallappa K. Kolar; Lev N. Novikov; Paul J. Kingham; Mikael Wiberg; Elisabet Åkesson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; spinal cord injury; peripheral nerve injury; mesenchymal stem cells; regeneration; neurotrophic factor; angiogenic factor;

    Abstract : Traumatic injuries to the spinal cord (SCI) and peripheral nerve (PNI) affect several thousand people worldwide every year. At present, there is no effective treatment for SCI and despite continuous improvements in microsurgical reconstructive techniques for PNI, many patients are still left with permanent, devastating neurological dysfunction. READ MORE