Search for dissertations about: "population PK model using NONMEM"
Showing result 1 - 5 of 10 swedish dissertations containing the words population PK model using NONMEM.
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1. Models for Ordered Categorical Pharmacodynamic Data
Abstract : In drug development clinical trials are designed to investigate whether a new treatment is safe and has the desired effect on the disease in the target patient population. Categorical endpoints, for example different ranking scales or grading of adverse events, are commonly used to measure effects in the trials. READ MORE
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2. Covariate Model Building in Nonlinear Mixed Effects Models
Abstract : Population pharmacokinetic-pharmacodynamic (PK-PD) models can be fitted using nonlinear mixed effects modelling (NONMEM). This is an efficient way of learning about drugs and diseases from data collected in clinical trials. READ MORE
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3. Using Pharmacokinetic and Pharmacodynamic Principles to Evaluate Individualisation of Antibiotic Dosing – Emphasis on Cefuroxime
Abstract : Cefuroxime is a renally eliminated antibiotic used against a variety of different bacterial infections. The pharmacokinetics (PK) for cefuroxime was studied in 97 hospitalized patients using population analysis. To be able to measure cefuroxime in human serum a new sensitive analytical method was developed using mass spectrometry detection. READ MORE
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4. Pharmacometric Approaches to Improve Dose Individualization Methods in Hemophilia A
Abstract : Hemophilia A is a bleeding disorder caused by the lack of functional coagulation factor VIII (FVIII). The overall aim of this thesis was to improve dose individualization of FVIII replacement therapy in hemophilia A using pharmacometric approaches. READ MORE
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5. Mechanism-Based Pharmacokinetic and Pharmacodynamic Modelling of Paclitaxel
Abstract : Paclitaxel (Taxol®) is now widely used against breast, ovarian and non-small-cell lung cancer. Anticancer agents generally have narrow therapeutic indices, often with myelosuppression (mainly neutropenia) as dose-limiting side effect. READ MORE