Search for dissertations about: "population and functional genomics"
Showing result 1 - 5 of 24 swedish dissertations containing the words population and functional genomics.
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1. Complex disease genetics : Utilising targeted sequencing and homogeneous ancestry
Abstract : The complex disease investigations presented in this thesis aimed to provide new information regarding underlying genetics by using targeted sequencing and ethnically homogeneous cohorts. This work moved past current methodologies and addressed data stratification issues, that might have been hindering new findings. READ MORE
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2. Functional genomics of diapause in two temperate butterflies
Abstract : Natural selection will act on a given phenotype to maximize fitness in a particular environment, even if this would result in reduced fitness in other environments. In insects some of the strongest selection pressures act on timing life cycles to seasonal variation in environmental conditions, in order to maximize growth, reproduction, and to anticipate the onset of winter. READ MORE
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3. Immunity & the butterfly : A functional genomic study of natural variation in immunity
Abstract : Butterflies are ubiquitous and abundant, occurring in a wide variety of environments that contain diverse microbial communities with varied pathogenic pressures. These pathogens and parasites present a constant threat to organisms, and have led to the evolution of complex and intricate immune responses. READ MORE
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4. From geography to genes: evolutionary perspectives on salinity tolerance in the brackish water barnacle Balanus improvisus
Abstract : How species respond to changes in their environment is a fundamental question in biology. This has become an increasingly important issue as anthropogenic effects of climate change and biological invasions have major impacts on marine ecosystems worldwide. READ MORE
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5. Dynamics of inbreeding and genetic rescue in a small population
Abstract : Isolation at small population size can reduce individual fitness and impede population growth caused by inbreeding and genetic drift (i.e. inbreeding depression). Inbreeding depression can however be circumvented by gene flow from unrelated individuals through masking of recessive deleterious alleles and contribute to population persistence (i. READ MORE