Search for dissertations about: "preclinical lymphoma"

Showing result 1 - 5 of 12 swedish dissertations containing the words preclinical lymphoma.

  2. 1. Potential New Drugs in Lymphoma

    Author : Maryam Delforoush; Gunilla Enblad; Mattias Berglund; Christina Drott; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lymphoma; diffuse large B-cell lymphoma; DLBCL; picropodophyllin; PPP; J1; melflufen; prodrug; cancer therapeutics; alkylating agents; b-AP15; proteasome inhibitors; DUB inhibition; UCHL5; USP14;

    Abstract : Lymphomas are malignant tumours arising from cells in the lymphatic system. They are classified as B-cell lymphomas, T-cell lymphomas and Hodgkin lymphoma (HL). Of the B-cell lymphomas, one of the most common is diffuse large B-cell lymphoma (DLBCL). READ MORE

  4. 2. Anticancer Activity of Melflufen : Preclinical Studies of a Novel Peptidase-Potentiated Alkylator

    Author : Sara Strese; Joachim Gullbo; Rolf Larsson; Mårten Fryknäs; Sigurd Vitols; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancertherapy; preclinical studies; melflufen; aminopeptidase-potentiated; cancer; angiogenesis; Klinisk farmakologi; Clinical Pharmacology;

    Abstract : Melflufen (melphalan flufenamide, chemical name L-melphalanyl-p-L-fluorophenylalanine ethyl ester hydrochloride, previously called J1) is a derivative of the classical alkylating agent melphalan. Melflufen is potentiated by hydrolytic cleavage by aminopeptidase N (APN), leading to high intracellular concentrations of alkylating moieties and subsequent cell death. READ MORE

  5. 3. Anaplastic lymphoma kinase activity, a therapeutic target, suppresses neuroblastoma cell differentiation

    Author : Joachim T. Siaw; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; ALK; 11q.; DLG2; SP1; differentiation; crizotinib; ceritinib; brigatinib;

    Abstract : Neuroblastoma (NB) is the most common extracranial pediatric solid malignancy caused by the failed differentiation of precursor cells of the developing sympathetic nervous system. NB accounts for about 15% of childhood cancer-related deaths. READ MORE

  6. 4. Preclinical and Clinical Development of the Novel Cyanoguanidine CHS 828 for Cancer Treatment

    Author : Peter Hovstadius; Rolf Larsson; Elin Lindhagen; Martin Höglund; Sigurd Vitols; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical drug development; CHS 828; Cyanoguanidines; Oncology; Clinical Drug Development; Klinisk läkemedelsutveckling; Pharmaceutical chemistry; Läkemedelskemi;

    Abstract : CHS 828 is a cyanoguanidine with anti-tumour properties which has shown promising effects in several preclinical models. This thesis describes both preclinical and clinical studies aiming to investigate disease specific activity, clinical tolerability and efficacy of CHS 828. READ MORE

  7. 5. ROR1 – a druggable target : preclinical studies of ROR1 and combinatorial partners in malignancies

    Author : Amineh Ghaderi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cancer cells are masters of adaption, and their ability to sustain proliferative signaling presents a complicated challenge to cancer treatment. Therefore, novel drugs that attack key drivers of cancer cell growth are urgently needed. READ MORE