Search for dissertations about: "prenylation"
Showing result 1 - 5 of 10 swedish dissertations containing the word prenylation.
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1. Protein Prenylation in Higher Eukaryotes
Abstract : Protein prenylation is a post-translational process where proteins become covalently modified by an isoprenoid group. This modification adds hydrophobicity to the proteins. For all prenylated proteins identified to date, the prenyl group is an absolute requirement for their biological functions. READ MORE
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2. Protein modification with hydrophobic prenyl groups in malignant cells
Abstract : Mevalonate (MVA) is the key intermediate in the isoprene synthetic pathway leading to the formation of a number of biologically important lipid molecules. It is well known that inhibition of MVA synthesis blocks the cell cycle progression of mammalian cells, a fact suggesting that some isoprenoids derived from MVA are required for cell proliferation. READ MORE
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3. Statins, Lipids, and Mutations: Consequences for the Heart and Immune System
Abstract : CAAX proteins are a group of proteins that undergo a three-step protein maturation process that renders the proteins carboxyl-terminus hydrophobic and prone to localize to cellular membranes, where they have their primary function. The first step in this process is called prenylation, which is the covalent attachment of a lipid, either a 15-carbon farnesyl or a 20-carbon geranylgeranyl lipid, to the carboxyl-terminal cysteine residue by the enzymes farnesyltransferase (FTase) and geranylgeranyltransferase type I (GGTase-I), respectively. READ MORE
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4. Defining the importance of protein geranylgeranylation in innate immunity
Abstract : RHO family proteins and other intracellular proteins are prenylated with a 20-carbon lipid—a product of the cholesterol synthesis pathway—by protein geranylgeranyltransferase type I (GGTase-I). Prenylation is widely believed to target proteins to membranes where they encounter effector molecules that stimulate GTP-binding and activation. READ MORE
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5. Progesterone receptor-mediated effects on apoptosis in periovulatory granulosa cells
Abstract : The most common fate of developing ovarian follicles is demise due to a process known as atresia. Regulation of atresia is dependent on the developmental stage of the follicles, resulting in a continuous reduction of the number of follicles as they differentiate and grow towards ovulation. READ MORE
