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Showing result 1 - 5 of 7 swedish dissertations matching the above criteria.

2. 1. Ultrastructural Studies of the Airway Epithelium in Airway Diseases

   Author : Eyman Shebani; Godfried M. Roomans; Marie Johannesson; Anil Mehta; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Morphology; asthma; cilia; corticosteroids; cytokines; desmosomes; Gaucher’s disease; montelukast; primary ciliary dyskinesia; transmission electron microscopy; Morfologi; Morphology; cell biology; pathology; Morfologi; cellbiologi; patologi;

   Abstract : Ultrastructural studies of airway epithelium in airway disease are important for diagnosis and understanding the underlying pathology which helps clinicians to improve the patients' treatment.Airway biopsies from a 5-month old boy with respiratory problems and gastro-oesophageal reflux were studied by transmission electron microscopy (TEM). READ MORE

4. 2. Particles in small airways : mechanisms for deposition and clearance and pharmacokinetic assessments of delivered dose to the lung

   Author : Maria Lindström; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Lung deposition; clearance; small airways; pharmacokinetic; cystic fibrosis; primary ciliary dyskinesia; asthma; sodium cromoglycate;

   Abstract : BACKGROUND: Knowledge about lung deposition and clearance from airways of inhaled particles/drugs are essential for evaluation of health effects of inhaled pollutants and to achieve optimal drug dose to the lung. The primary defence mechanism in the conducting airways is the mucociliary clearance (MCC). READ MORE

5. 3. Revealing the architecture and composition of the sperm flagellum tip

   Author : Davide Zabeo; Göteborgs universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell biology; Structural biology; Microtubules; Electron microscopy; Cryo-electron microscopy; Cryo-electron tomography;

   Abstract : The eukaryotic flagellum is a membrane-bound protruding organelle with a cytoskeleton of microtubules. Flagella are found in unicellular as well as multicellular organisms, performing a variety of functions. READ MORE

6. 4. Studies of the Elemental Composition of Airway Surface Liquid with Relevance to Cystic Fibrosis

   Author : Viengphet Vanthanouvong; Godfried M. Roomans; Isabelle Sermet-Gaudelus; Uppsala universitet; []
   Keywords : Anatomy; airway surface liquid; cystic fibrosis; Na; K; Cl; X-ray microanalysis; Anatomi;

   Abstract : Cystic fibrosis (CF) is an inherited disease with symptoms mainly in the respiratory tract. The airway epithelium is covered with a thin layer of fluid, the airway surface liquid (ASL). The volume and composition of ASL are important in the pathogenesis of cystic fibrosis. The composition of ASL was determined. READ MORE

7. 5. Methods for Processing and Analysis of Biomedical TEM Images

   Author : Amit Suveer; Ida-Maria Sintorn; Carolina Wählby; Natasa Sladoje; Jari Hyttinen; Uppsala universitet; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; image analysis; image processing; deep learning; transmission electron microscopy; denoising; super-resolution reconstruction; registration; detection; Computerized Image Processing; Datoriserad bildbehandling;

   Abstract : Transmission Electron Microscopy (TEM) has the high resolving capability and high clinical significance; however, the current manual diagnostic procedure using TEM is complicated and time-consuming, requiring rarely available expertise for analyzing TEM images of the biological specimen. This thesis addresses the bottlenecks of TEM-based analysis by proposing image analysis methods to automate and improve critical time-consuming steps of currently manual diagnostic procedures. READ MORE