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Showing result 1 - 5 of 328 swedish dissertations matching the above criteria.

  2. 1. Studies of high mobility group chromosomal protein 1 as a pro-inflammatory cytokine

    Author : Gail E Mullins; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HMGB1; endothelial cells; pro-inflammatory; cytokine; RAGE;

    Abstract : High mobility group box chromosomal protein 1 (HMGB 1) is a nuclear protein recently recognised as a pro-inflammatory cytokine with implications both in acute and in chronic inflammation. HMGB1 has been reported to act as a late mediator of septic shock in mice. READ MORE

  4. 2. Transcriptional and Epigenetic Regulation of Epithelial-Mesenchymal Transition

    Author : E-Jean Tan; Aristidis Moustakas; Carl-Henrik Heldin; Geert Berx; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGFβ; EMT; HMGA2; Snail; Twist; E-cadherin; epigenetics; invasion; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : The transforming growth factor beta (TGFβ) is a cytokine that regulates a plethora of cellular processes such as cell proliferation, differentiation, migration and apoptosis. TGFβ signals via serine/threonine kinase receptors and activates the Smads to regulate gene expression. READ MORE

  5. 3. Identification and functional characterization of novel thioredoxin systems

    Author : Anastasios E Damdimopoulos; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Antioxidants; Reactive Oxygen Species; Tbioredoxin; Tbioredoxin Reductase;

    Abstract : Thioredoxins (Trx) are a class of small multifunctional 12-kDa proteins that are characterized by the redox active site Trp-Cys-Gly-Pro-Cys (WCGPC). In the oxidized (inactive) form of Trx (Trx-S2), the two cysteines at the active site form a disulfide bond. READ MORE

  6. 4. Strategies for modulation of dendritic cell responses

    Author : Annette E Sköld; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : With increased knowledge in dendritic cell (DC) biology, innate immune receptors and their ligands, and the shaping of adaptive responses, refined approaches to modulate our immune system are today emerging as treatment strategies for chronic infections and severe cancers. At the center of attention stand DCs – the innate immune cells that orchestrate the adaptive immune responses. READ MORE

  7. 5. Functional details of human HtrA2 protease studied by NMR spectroscopy

    Author : Emelie E. Aspholm; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; HtrA2; nuclear magnetic resonance; protein quality control; neurodegenerative disease; apoptosis;

    Abstract : Cells rely on an array of cellular machineries in the protein quality control system (PQC) to maintain the health of the collective proteome. The HtrA family of serine proteases are found in all kingdoms of life and function in the PQC by degrading damaged and aggregated proteins as well as by acting as molecular chaperones. READ MORE