Search for dissertations about: "proliferation signature"

Showing result 1 - 5 of 42 swedish dissertations containing the words proliferation signature.

  2. 1. Genetic and Epigenetic Profiling of Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia

    Author : Anna Margrét Halldórsdóttir; Richard Rosenquist; Reiner Siebert; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mantle cell lymphoma; chronic lymphocytic leukemia; copy number aberration; proliferation signature; TP53; SNP array; methylation array; Haematology; Hematologi; Clinical genetics; Klinisk genetik; Molecular biology; Molekylärbiologi; Tumour biology; Tumörbiologi; Medicinsk genetik; Medical Genetics; Oncology; Onkologi; Molekylär medicin; Molecular Medicine; Patologi; Pathology;

    Abstract : Mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL) both belong to the group of mature B-cell malignancies. However, MCL is typically clinically aggressive while the clinical course of CLL varies. READ MORE

  4. 2. Biological signature of HER2-positive breast cancer

    Author : Breezy Malakkaran Lindqvist; Sten Wingren; Torbjörn Nilsson; Ingrid Hedenfalk; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HER2 breast cancer; SLC25A43; CpG island; DNA methylation; Homeobox genes; FOXO3a; FOXG1; Biomedicin; Biomedicine;

    Abstract : Human epidermal growth factor receptor 2 (HER2) overexpressing breast cancers (HER2+ breast cancer) are associated with an aggressive disease course. This thesis is focused on improving the understanding of the biological signature of HER2+ breast cancer. READ MORE

  5. 3. Prognostic factors in breast cancer with a focus on the role of tumour proliferation

    Author : Claudette Falato; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Ki67 is the most commonly used marker of proliferation in breast cancer. The general aim of the thesis was to investigate the prognostic role of Ki67 and its interplay with other prognostic factors in breast cancer cohorts. READ MORE

  6. 4. Transcriptional analysis of mantle cell lymphoma - a global search for cellular origin and therapeutic targets

    Author : Sara Ek; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; oncology; cancerology; Cytologi; onkologi; Cytology; somatic mutation; microarray; tumour; mantle cell lymphoma; B cell;

    Abstract : This thesis is based upon four original papers describing the characterisation of mantle cell lymphoma (MCL) tumours and cell lines in comparison with different populations of normal B cells. Gene expression profiling, which were used in the studies, has during recent years developed as an important tool in characterisation of different types of malignancies. READ MORE

  7. 5. Computational Analysis of Tumour Heterogeneity

    Author : Stefanie Friedrich; Erik Sonnhammer; Martin Hemberg; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; tumour heterogeneity; human genome and gene expression analyses; pathway annotation; fusion transcript detection; copy number calling; and high-resolution data; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

    Abstract : Every tumour is unique and characterised by its genetic, epigenetic, phenotypic, and morphological signature. The diversity observed between and within tumours, and over time, is termed tumour heterogeneity. An increased heterogeneity within a tumour correlates with cancer progression, higher resistance rates, and poorer outcome. READ MORE