Search for dissertations about: "protein classification"

Showing result 1 - 5 of 137 swedish dissertations containing the words protein classification.

2. 1. Classification, Evolution, Pharmacology and Structure of G protein-coupled Receptors

   Author : Malin C Lagerström; Helgi B. Schiöth; Robert Fredriksson; Anthony J. Harmar; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; Classification; Structure; Pharmacology; Evolution; G protein-coupled receptor; Farmakologi; Pharmacological research; Farmakologisk forskning;

   Abstract : G protein-coupled receptors (GPCR) are integral membrane proteins with seven α-helices that translate a remarkable diversity of signals into cellular responses. The superfamily of GPCRs is among the largest and most diverse protein families in vertebrates. READ MORE

4. 2. From protein sequence to structural instability and disease

   Author : Lixiao Wang; Uwe Sauer; Sven Hovmöller; Umeå universitet; []
   Keywords : protein domain; remote homologue; intrinsically disorder unstructured proteins; protein function; point mutation; protein family protein stability; HMMs; CRFs; SVMs;

   Abstract : A great challenge in bioinformatics is to accurately predict protein structure and function from its amino acid sequence, including annotation of protein domains, identification of protein disordered regions and detecting protein stability changes resulting from amino acid mutations. The combination of bioinformatics, genomics and proteomics becomes essential for the investigation of biological, cellular and molecular aspects of disease, and therefore can greatly contribute to the understanding of protein structures and facilitating drug discovery. READ MORE

5. 3. Transmembrane Proteins and Protein Structure Prediction : What we can learn from Computational Methods

   Author : John Lamb; Arne Elofsson; Paolo Marcatili; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein structure prediction; contact prediction; transmembrane protein; topology prediction; machine learning; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

   Abstract : A protein’s 3D-structure is essential to understand how proteins function and interact and how biochemical processes proceed in organic life. Despite the advancement in experimental methods, it remains expensive and time-consuming to determine protein structure experimentally. READ MORE

6. 4. The labyrinth of protein classification: a pipeline forselection and classification of biological data

   Author : Benedetta Pelosi; Neus Visa; Antonio Barragan; Stefan Jansson; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; pipeline; filtering; machine learning; deep learning; computational biology; bioinformatics; mitochondrial metabolism; carotenoid biosynthesis; orthologs; protein analyses; statistics; biokemi med inriktning mot bioinformatik; Biochemistry towards Bioinformatics; statistik; Statistics;

   Abstract : Recent progress in fundamental biological sciences and medicine has considerably increased the quantity ofdata that can be studied and processed. The main limitation now is not retrieving data, but rather extractinguseful biological insights from the large datasets accumulated. READ MORE

7. 5. Protein stability and mobility in live cells : Revelation of the intracellular diffusive interaction organization mechanisms

   Author : Xin Mu; Mikael Oliveberg; Johan Elf; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; diffusive interactions; macromolecular crowding; protein thermodynamic stability; protein mobility; in-cell NMR; Hofmeister series; Biochemistry; biokemi;

   Abstract : Biochemical processes inside living cells take place in a confined and highly crowded environment. As such, macromolecular crowding, one of the most important physicochemical properties of cytoplasm, is an essential element of cell physiology. READ MORE