Search for dissertations about: "proteolytic cleavage"

Showing result 1 - 5 of 86 swedish dissertations containing the words proteolytic cleavage.

2. 1. Computational Prediction Models for Proteolytic Cleavage and Epitope Identification

   Author : Liwen You; Beräkningsbiologi och biologisk fysik - Genomgår omorganisation; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; medical informatics; biomathematics biometrics; Bioinformatics; SVM; sequence analysis; rule extraction; protease-peptide interaction; OSRE; MHC; immunology; HIV; hierarchical method; HCV; Gaussian process; false positive; epitope; cleavage specificity; cleavage prediction; binding affinity; caspase; Bioinformatik; medicinsk informatik; biomatematik; Computer science; numerical analysis; systems; control; Datalogi; numerisk analys; system; kontroll; Binding affinity; Bioinformatics;

   Abstract : The biological functions of proteins depend on their physical interactions with other molecules, such as proteins and peptides. Therefore, modeling the protein-ligand interactions is important for understanding protein functions in different biological processes. READ MORE

4. 2. Assembly and proteolytic cleavages of gel-forming mucins

   Author : Martin Lidell; Göteborgs universitet; []
   Keywords : mucins; MUC2; MUC5AC; dimer; trimer; cleavage; Entamoeba histolytica; cysteine protease;

   Abstract : Gel-forming mucins are large glycoproteins constituting the main structural component of themucus layer protecting epithelial surfaces of the body. This thesis aims to a deeper understandingof how gel-forming mucins are synthesized and assembled, and how they may interact with othermolecules. READ MORE

5. 3. Expression and novel function of CD43 in colon cancer cells

   Author : Christian X Andersson; Göteborgs universitet; []
   Keywords : CD43; leukosialin; sialophorin; mucin; nuclear localization; nuclear signaling; Wnt-signaling; beta-catenin; regulated intramembrane cleavage; RIP; proteolytic cleavage;

   Abstract : CD43 is a transmembrane protein containing an extracellular domain that is extensively O-glycosylated, and a relatively large intracellular domain with a conserved sequence between human, rat and mouse. It is frequently expressed in haematopoietic cell lines where it functions as a regulator of cell adhesiveness, a signal transducer and a cytoskeleton-interacting protein. READ MORE

6. 4. Haptoglobin: Biosynthesis and Evolution

   Author : Krzysztof B. Wicher; Erik Fries; John W. M. Creemers; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; haptoglobin; cleavage; C1r-LP; evolution; vertebrate; endoplasmic; Golgi; complement; Molekylärbiologi; Molecular biology; Molekylärbiologi;

   Abstract : Haptoglobin (Hp) is a serum protein known for its ability to form a tight complex with hemoglobin (Hb) and thereby inhibiting the oxidative activity of Hb. Mammalian Hp is synthesized as a precursor (proHp) that undergoes proteolytic cleavage by a previously unidentified enzyme in the endoplasmic reticulum (ER). READ MORE

7. 5. Modulation of PDGF receptors function by posttranslational modifications

   Author : Kehuan Wang; Carl-Henrik Heldin; Johan Lennartsson; Natalia Papadopoulos; Jean-Baptiste Demoulin; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF signaling; receptor tyrosine kinase; ubiquitination; DUB; STAT3; SUMO; SUMOylation; cleavage; autophagy; SQSTM1 p62; LC3; GABARAP; bafilomycin A1; Medicinsk biokemi; Medical Biochemistry; Medical Cell Biology; Medicinsk cellbiologi;

   Abstract : The platelet-derived growth factor receptors (PDGFRs) play important roles in multiple cellular processes including cell survival, cell growth and cell migration. Dysregulation of PDGFRs causes aberrant PDGF signaling, which leads to various diseases. READ MORE