Search for dissertations about: "puumala"

Showing result 1 - 5 of 22 swedish dissertations containing the word puumala.

2. 1. Study of pathogenesis and immune response in human Puumala virus infection

   Author : Therese Thunberg; Clas Ahlm; Jonas Klingström; Brian Hjelle; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hantavirus; puumala virus; immune response; viral load; NK cells; T cells; cytokines; disease severity; Infectious Diseases; infektionssjukdomar;

   Abstract : Hantaviruses can cause two severe human diseases: hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS). Hantaviruses are spread to humans mainly through inhalation of infectious virions, secreted from infected rodents. The human diseases are characterized by an increased capillary leakage syndrome. READ MORE

4. 2. Implications of Local Puumala Hantavirus Genetics and Epidemiology for Diagnostics and Vaccine Development

   Author : Patrik Johansson; Fredrik Elgh; Göran Bucht; Detlev Krüger; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Communicable diseases; hantavirus; Puumala virus; nephropathia epidemica; genome sequence; glycosylation; linear DNA vaccine; microarray; identification; genetic variability; Infektionssjukdomar; Infectious diseases; Infektionssjukdomar; medicinsk virologi; Medical Virology;

   Abstract : Puumala viruses, a member of the Hantavirus genus in the Bunyaviridae family, are enveloped by a lipid bilayer and possesses a tripartite single stranded RNA genome with negative polarity. The hantaviruses encode four proteins: a nucleocapsid protein (N), two membrane spanning glycoproteins (GN and GC) and a RNA dependent RNA polymerase (RdRp). READ MORE

5. 3. Puumala hantavirus : immune responses and vaccines

   Author : Cristina de Carvalho Nicacio; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Hantavirus; Puumala virus; nucleocapsid protein; neutralizing antibodies; Fab fragment; combinatorial library; phage-display; IgA; cellular immunity; cross-protection; intranasal vaccination;

   Abstract : Hantaviruses (family Bunyaviridae) is a group of closely related zoonotic rodent-borne viruses that are transmitted to humans through inhalation of infected rodent excreta. They cause hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS) with varying degree of severity depending on the causative virus. READ MORE

6. 4. Distribution of puumala virus in Sweden

   Author : Clas Ahlm; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : Puumala virus, belonging to the genus hantavirus, is the causative agent of nephropathia epidemica (NE), a relatively mild form of hemorrhagic fever with renal syndrome. Puumala virus occurs endemically in Central and Northern Europe and Western Russia. READ MORE

7. 5. Cardiopulmonary involvement in Puumala hantavirus infection

   Author : Johan Rasmuson; Clas Ahlm; Anders Blomberg; Jamshid Pourazar; Gregory J. Mertz; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hemorrhagic fever with renal syndrome; hantavirus; echocardiography; respiratory function tests; computed tomography; bronchoalveolar lavage; biopsy; cytotoxic T cells; disease severity; Infectious Diseases; infektionssjukdomar;

   Abstract : Puumala hantavirus (PUUV) causes hemorrhagic fever with renal syndrome in Europe. After inhalation of virus shed by bank voles, the virus systemically targets the vascular endothelium leading to vascular dysfunction and leakage. READ MORE