Search for dissertations about: "pyrimethamine"

Showing result 1 - 5 of 17 swedish dissertations containing the word pyrimethamine.

  2. 1. Development of Analytical Methods for the Determination of Antimalarials in Biological Fluids

    Author : Daniel Blessborn; Yngve Bergqvist; Anders Helander; Högskolan Dalarna; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Malaria; Chloroquine; Quinine; Sulfadoxine; Pyrimethamine; Mefloquine; Lumefantrine; Amodiaquine; Pyronaridine; Proguanil; Atovaquone; Sampling paper; Dried blood spots; Capillary blood; Antimalarial drugs; Solid-phase extraction; Liquid chromatography.; Chemistry;

    Abstract : The aim of this thesis was to develop analytical methods for measuring antimalarial drugs in biological fluids. Solid phase extraction (SPE) was used for the enrichment and purification of the drugs. READ MORE

  4. 2. Fixed-dose chloroquine and sulfadoxine/pyrimethamine treatment of malaria : outcome and pharmacokinetic aspects

    Author : Celestino Obua; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: A pre-packaged fixed-dose formulation of chloroquine (CQ) and sulfadoxine/pyrimethamine (SIP) combination (Homapak) is widely used for the treatment of falciparum malaria in the Home Based Management of Fevers program for Ugandan children. Until the present study, the efficacy, pharmacokinetics and drug interactions of the dose regimen of the product were not known. READ MORE

  5. 3. Optimization of intermittent preventive therapy for malaria during pregnancy : effectiveness of dihydroartemisinin-piperaquine versus sulfadoxine-pyrimethamine

    Author : Eulambius Mathias Mlugu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Malaria is a Tropical disease caused by different parasites species of genius Plasmodium. Because of pregnancy associated lowered immunity, women who are pregnant are at higher risk to malaria infection than non-pregnant women. READ MORE

  6. 4. Managing childhood malaria in rural Tanzania : focusing on drug use and resistance

    Author : Jaran Eriksen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Malaria; Policy change; Sulfadoxine-pyrimethamine; Chloroquine; Tanzania; Health workers; Drug resistance;

    Abstract : Background: Malaria is a leading cause of death in underfive children in Africa. Due to the spread of chloroquine (CQ) resistance, sub-Saharan African countries such as Tanzania have changed their malaria treatment policies. In 2001 Tanzania replaced CQ with sulfadoxine/pyrimethamine (SP) as first line malaria treatment. READ MORE

  7. 5. Treatment of uncomplicated malaria in Guinea-Bissau

    Author : Paul Erik Kofoed; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Chloroquine; sulphadoxine; pyrimethamine; amodiaquine; quinine; artemisinine; malaria; children; Guinea-Bissau; efficacy; effectiveness.;

    Abstract : Treatment of malaria has become increasingly difficult due to high levels of resistance to the cheap and commonly used antimalarials. In Guinea-Bissau, the first line drug is chloroquine (CQ), the second line drug is sulfadoxine-pyrimethamine (S/P), and the third line therapy is quinine (QU). READ MORE