Search for dissertations about: "radiosensitization"

Showing result 1 - 5 of 8 swedish dissertations containing the word radiosensitization.

  2. 1. Searching for Synergy : Radiosensitization of 177Lu-DOTATATE

    Author : Sara Lundsten; Marika Nestor; Hanna Björkelund; Katarina Edwards; Julie Nonnekens; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; targeted radionuclide therapy; radiosensitization; p53; MDM2 MDM4 inhibition; HSP90; drug synergy; drug delivery; lipid nanoparticles; lipodisks; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Abstract : Cancers presents a major health challenge, and there is a pressing need to develop new therapeutic strategies. Surgery, chemotherapy and radiation are the most commonly used treatments for cancer today. Radiation can be given as targeted radionuclide therapy (TRT), i.e. READ MORE

  4. 2. Towards Personalized Cancer Therapy : New Diagnostic Biomarkers and Radiosensitization Strategies

    Author : Diana Spiegelberg; Marika Nestor; Bo Stenerlöw; Johan Lennartson; Theodosia Maina-Nock; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tumor targeting; radionuclide targeting; HSP90 inhibition; AT13387; radiosensitization; molecular imaging; combination treatment; EGFR; CD44v6; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Abstract : This thesis focuses on the evaluation of biomarkers for radio-immunodiagnostics and radio-immunotherapy and on radiosensitization strategies after HSP90 inhibition, as a step towards more personalized cancer medicine. There is a need to develop new tracers that target cancer-specific biomarkers to improve diagnostic imaging, as well as to combine treatment strategies to potentiate synergistic effects. READ MORE

  5. 3. Targeted radiotherapy in metastatic neuroendocrine tumours: clinical and experimental studies

    Author : Anna-Karin Elf; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuroendocrine tumour; peptide receptor radionuclide therapy; somatostatin receptor 2 expression; radiosensitization; radioembolization; diffusion weighted imaging;

    Abstract : ABSTRACT Neuroendocrine tumours (NET) often present at a metastatic stage, which diminishes the possibility for curative surgery. Peptide receptor radiotherapy (PRRT) with 177Lu-DOTATATE targets somatostatin receptors, which are overexpressed on NET cells. PRRT results in symptom relief and often tumour control of NETs, but rarely cure. READ MORE

  6. 4. ARCON in experimental and clinical radiotherapy

    Author : Ana Maria Rojas Callejas; Björn Zackrisson; René-Olivier Mirimanoff; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; ARCON; tumours; normal tissues; radiosensitization; carbogen; nicotinamide; repair inhibition; therapeutic gain; rodents; humans; Onkologi; Oncology; Onkologi; onkologi; Oncology;

    Abstract : xHypoxia and repopulation of tumour clonogens are two important determinants of treatment outcome in radiotherapy. In general clinical evidence indicates that loco-regional control may be reduced with long overall treatment times and for tumours with low pre-treatment levels of oxygen. READ MORE

  7. 5. Precision medicine and targeted therapy : Turning the tables on cancer

    Author : Anja Mortensen; Marika Nestor; Gregory Adams; Uppsala universitet; []
    Keywords : p53 cancers; PM2; radiosensitization; radio-immunotherapy; MDM2 X inhibition; combination therapy; targeted radionuclide therapy; CD44v6; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Abstract : An extended understanding of the molecular characteristics of cancer has led to a revolution within the field of precision medicine. This thesis explores the utilization of two targets for precision medicine, namely, CD44v6 and murine double-minute 2 and X (MDM2/X). READ MORE