Search for dissertations about: "radiotracer chemistry"

Showing result 1 - 5 of 8 swedish dissertations containing the words radiotracer chemistry.

  2. 1. Liquid Chromatography – Mass Spectrometry Analysis of Short-lived Tracers in Biological Matrices : Exploration of Radiotracer Chemistry as an Analytical Tool

    Author : Martin Lavén; Karin Markides; Bengt Långström; Rolf Ekman; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; liquid chromatography - mass spectrometry; radiotracer chemistry; positron emission tomography; biological samples; radionuclide imaging; Analytisk kemi; Analytical chemistry; Analytisk kemi;

    Abstract : Liquid chromatography – mass spectrometry (LC-MS) methods were developed for the analysis of positron emission tomography (PET) radiotracers in biological matrices. Additionally, radiotracer chemistry was explored as an analytical tool for supporting LC-MS method development and imaging molecular interactions in miniaturised chemical analysis systems. READ MORE

  4. 2. Development of Palladium-Promoted 11C/12C-Carbonylations and Radiosynthesis of Amyloid PET Ligands

    Author : Patrik Nordeman; Gunnar Antoni; Mats Larhed; Luke R Odell; Antony D Gee; Uppsala universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Palladium; Carbonylation; Positron emission tomography; PET; Carbon-11; Fluor-18; Radiochemistry; Amyloidosis; Palladium; Karbonyleringar; Positronemissionstomografi; PET; Kol-11; Fluor-18; Radiokemi; Amyloidos; Pharmaceutical Science; Farmaceutisk vetenskap; Chemistry with specialization in Organic Chemistry; Kemi med inriktning mot organisk kemi; Medicinal Chemistry; Läkemedelskemi;

    Abstract : In the first part of this thesis, palladium(0)-catalyzed and -mediated carbonylations are discussed. Paper I describes a new method for the safe, efficient use of a solid carbon monoxide source in the synthesis of primary and secondary benzamides. READ MORE

  5. 3. Synthesis of Organofluorine Compounds and Allenylboronic Acids - Applications Including Fluorine-18 Labelling

    Author : Denise N. Meyer; Kálmán J. Szabó; Dominique Cahard; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; boron; allenylboronic acid; BINOL; homopropargyl alcohol; organocatalyst; organoboron; organofluorine; fluorine; fluorine-18; late-stage; labelling; labeling; nucleophilic; electrophilic; fluorination; positron emision tomography; PET; radiotracer; hypervalent iodine; benziodoxole; benzoxazepines; diaryliodonium salt; metal-free; neutrophil elastase; NE; neutrophil elastase inhibitor; trifluoromethylation; trifluoromethylthiolation; difluoro enol silyl ethers; organisk kemi; Organic Chemistry;

    Abstract : This work is focused on two areas: the chemistry of organofluorine and organoboron compounds. In the first chapter, a copper-catalysed synthesis of tri- and tetrasubstituted allenylboronic acids is presented. Extension of the same method leads to allenylboronic esters. READ MORE

  6. 4. Functional regulation of the dopaminergic system in vivo : Experimental and clinical studies with positron emission tomography

    Author : Richard Torstensson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

    Abstract : Positron emission tomography (PET) is a non-invasive imaging technique used to quantitate the kinetics of a radiotracer in such physiological processes as receptor binding and enzyme activity. Radiolabelled L-DOPA has previously been used as a tracer for the dopaminergic system. READ MORE

  7. 5. Synthesis and application of β-configured [18/19F]FDGs : Novel prosthetic CuAAC click chemistry fluoroglycosylation tools for amyloid PET imaging and cancer theranostics

    Author : Mathias Elgland; Peter Konradsson; Peter Nilsson; Per Hammarström; Olof Solin; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; FDG; clickable; PET; synthesis; in vivo imaging; theranostics;

    Abstract : Positron emission tomography (PET) is a non-invasive imaging method that renders three-dimensional images of tissue that selectively has taken up a radiolabelled organic compound, referred to as a radiotracer. This excellent technique provides clinicians with a tool to monitor disease progression and to evaluate how the patient respond to treatment. READ MORE