Search for dissertations about: "rat wistar"

Showing result 1 - 5 of 41 swedish dissertations containing the words rat wistar.

  2. 1. About hyaluronan in the hypertrophic heart : studies on coordinated regulation of extracellular matrix signalling

    Author : Urban Hellman; Anders Waldenström; Stellan Mörner; Anna Engström-Laurent; Lena Jonasson; Umeå universitet; []
    Keywords : hyaluronan; hyaluronan synthases; gene expression; extracellular matrix; cardiac hypertrophy; rat wistar; male ; cardiomyocytes; growth factors; fibroblasts; microvesicles; exosomes; MEDICINE; MEDICIN; Medicine; medicin;

    Abstract : Background. Myocardial hypertrophy is a risk factor for cardiovascular morbidity and mortality. Independent of underlying disease, the cardiac muscle strives in different ways to compensate for an increased workload. This remodelling of the heart includes changes in the extracellular matrix which will affect systolic and diastolic cardiac function. READ MORE

  4. 2. Diabetic osteopathy : a study in the rat

    Author : Tashfeen Ahmad; Karolinska Institutet; Karolinska Institutet; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Diabetes mellitus type 2; Goto-Kakizaki rat; bone mineral density; insulin-like growth factor-I; insulin-like growth factor binding protein 1; insulin-like growth factor binding protein 4; peripheral neuropathy; substance P; calcitonin gene-related peptide; neuropeptide Y; Diabetes mellitus type 2;

    Abstract : The present study on non-obese Goto-Kakizaki (GK) rats with type-2 diabetes and neuropathy was an attempt to describe and define pertinent features of diabetic osteopathy. Altogether, the study included 33 GK rats aged 12 and 20 months, and 36 age-matched Wistar rats as controls. READ MORE

  5. 3. Behavioral effects of female sex steroid hormones : models of PMS and PMDD in Wistar rats

    Author : Magnus Löfgren; Torbjörn Bäckström; Inga-Maj Johansson; Per Södersten; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; PMS; PMDD; rats; progesterone; estradiol; behavior; individual response; stress interaction; tolerance; withdrawal; learning and memory; anxiety.; Biological research on drug dependence; Biologisk beroendeforskning; Endocrinology; Endokrinologi; Obstetrics and gynaecology; Obstetrik och gynekologi; Pharmacological research; Farmakologisk forskning; Obstetrics and gynaecology; Obstetrik och gynekologi; Psychology; Psykologi; obstetrik och gynekologi; Obstetrics and Gynaecology;

    Abstract : Background Animal models can be used to mimic human conditions of psychopathology, and also as pre-clinical models to evaluate candidate drugs. With hormonal treatment it is possible to produce behavior in the rat which corresponds to the mental symptoms of pre-menstrual syndrome (PMS), and pre-menstrual dysphoric disorder (PMDD). READ MORE

  6. 4. Mechanisms of opiate tolerance and dependence in the rat

    Author : Orsolya Hoffman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Drug addiction is a complex phenomenon with various biological, psychological and social causes and consequences, which belongs to the major problems of today's society. Opiates have been used and misused for thousand of years and addiction to them develops both in humans and in animals. READ MORE

  7. 5. On the possible role of serotonin and angiotensin for the respiratory abnormalities observed in panic disorder and premenstrual dysphoria

    Author : Marie Olsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; panic disorder; premenstrual dysphoria; serotonin; paroxetine; PCPA; angiotensin; saralasin; respiration; respiratory variability; CO2; sodium lactate; female sex steroids; estrus cycle; Wistar rats;

    Abstract : Panic disorder and premenstrual dysphoria are accompanied by intriguing abnormalities related to the control of respiration, including enhanced responsiveness to CO2 and enhanced respiratory variability. These aberrations do not seem to be shared by other psychiatric disorders, but appear to be relatively unique for panic disorder and premenstrual dysphoria. READ MORE