Search for dissertations about: "receptor dimerization"
Showing result 1 - 5 of 26 swedish dissertations containing the words receptor dimerization.
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1. New Paradigms in GPCR Drug Discovery : Structure Prediction and Design of Ligands with Tailored Properties
Abstract : G protein-coupled receptors (GPCRs) constitute a large superfamily of membrane proteins with key roles in cellular signaling. Upon activation by a ligand, GPCRs transduce signals from the extracellular to the intracellular environment. READ MORE
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2. Structure and function of the HDL receptor SR-BI : scavenger receptor class B type I
Abstract : Low plasma levels of high-density lipoprotein (HDL) and high levels of low-density lipoprotein (LDL) are well-recognized risk factors for cardiovascular disease. The uptake and degradation of LDL cholesterol have been characterized in detail at the molecular level. Less is known about the metabolism and cellular uptake of HDL cholesterol. READ MORE
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3. Receptors for growth hormone and prolactin. Regulation and activation
Abstract : Cytokine receptor activation is dependent on ligand-induced receptor dimerization or oligomerization and subsequent activation of several intracellular proteins. Activation of Janus kinases (Jaks) is probably the first intracellular event that occurs after receptor dimerization. READ MORE
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4. EGFR- and HER2-Binding Affibody Molecules : Cellular studies of monomeric, dimeric and bispecific ligands
Abstract : Abnormal expression and signaling of the ErbB receptors is associated with the development and progression of several forms of cancer. In this thesis, new ErbB-targeting affibody molecules are evaluated regarding their cellular effects in vitro. READ MORE
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5. Design and engineering of human transferrin receptor 1 and its binding proteins
Abstract : The human transferrin receptor 1 (TfR) is central in maintaining adequate cellular iron levels with the iron carrier proteins transferrin (Tf) and ferritin (Ft). Known to bind TfR is also HFE, another iron regulatory protein, competing with Tf for receptor binding. READ MORE