Search for dissertations about: "receptor"

Showing result 1 - 5 of 4107 swedish dissertations containing the word receptor.

  2. 1. G protein-coupled receptor regulation: The role of protein interactions and receptor trafficking

    Author : Caroline Sandén; Drug Target Discovery; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; receptor trafficking; B1 receptor; receptor oligomerization; estrogen; GPER1; G protein-coupled estrogen receptor 1; EP24.15; BK; bradykinin; B1R; B2R; B2 receptor; GPCR; receptor maturation;

    Abstract : The superfamily of G protein-coupled receptors (GPCR) is the largest gene family in the human genome. GPCR-mediated signaling operates in every human cell, and about 50% of existing clinically useful drugs act through GPCR. READ MORE

  4. 2. Galanin receptor : studies with site-directed mutagenesis, agonists and antagonists

    Author : Kalev Kask; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : .... READ MORE

  5. 3. Evolution of Vertebrate Endocrine and Neuronal Gene Families : Focus on Pituitary and Retina

    Author : Daniel Ocampo Daza; Dan Larhammar; Marc Robinson-Rechavi; Uppsala universitet; []
    Keywords : phylogenetics; evolution; molecular evolution; gene family evolution; genome duplication; gene duplication; oxytocin receptor; vasopressin receptor; visual opsin; transducin; growth hormone; prolactin; somatolactin; growth hormone receptor; prolactin receptor; somatostatin receptor; SSTR; IGFBP; evolution; molekylär evolution; fylogeni;

    Abstract : The duplication of genes followed by selection is perhaps the most prominent way in which molecular biological systems gain multiplicity, diversity and functional complexity in evolution. Whole genome duplications (WGDs) therefore have the potential of generating an extraordinary amount of evolutionary innovation. READ MORE

  6. 4. Galanin receptor ligands

    Author : Johan Runesson; Ülo Langel; Lena Mäler; Stockholms universitet; []
    Keywords : Galanin; GALP; GPCR; Agonist; GalR; Chimeric peptide; Inositol phosphate production; Receptor specificity; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Abstract : In the nervous system galanin primarily displays a modulatory role. The galaninergic system consists of a number of bioactive peptides with a highly plastic expression pattern and three different receptors. The lack of receptor subtype selective ligands and antibodies have severely hampered the charac-terization of this system. READ MORE

  7. 5. Neurosteroids Induce Allosteric Effects on the NMDA Receptor : Nanomolar Concentrations of Neurosteroids Exert Non-Genomic Effects on the NMDA Receptor Complex

    Author : Tobias Johansson; Fred Nyberg; Pierre Le Grevès; Elisabeth Hansson; Uppsala universitet; []
    Keywords : Pharmaceutical pharmacology; Pharmacology; neurosteroids; NMDA receptor; NR2B subunit; ifenprodil; sigma receptor; anabolic androgenic steroids; allosteric modulation; non-genomic; Farmaceutisk farmakologi;

    Abstract : The neurosteroids constitute a group of powerful hormones synthesized and acting in the central nervous system. They participate in a number of important central processes, such as memory and learning, mood and neuroprotection. READ MORE