Search for dissertations about: "recombinant cell lines"

Showing result 1 - 5 of 59 swedish dissertations containing the words recombinant cell lines.

  2. 1. Investigating histidine-rich glycoprotein and T cell-specific adaptor as potential biomarkers and therapeutic targets

    Author : Tor Persson Skare; Lena Claesson-Welsh; Mats Hellström; Elin Sjöberg; Jonas Fuxe; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Histidine-rich glycoprotein; T cell-specifik adaptor; Lymphoma; Glioblastoma; Vascular permeability;

    Abstract : The endothelial cell (EC), the most important cell type in blood vessels, lines the vessel wall and provides vessel integrity. EC function is tightly regulated, and its dysregulation is a key element in many diseases including cardiovascular disease, cancer and several diseases of the eye. READ MORE

  4. 2. Neutral proteases of rodent mast cells

    Author : Carolina Lunderius; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Mast cell; serine protease; MMCP; RMCP; heparin; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; immunologi; Immunology;

    Abstract : Mast cells are important effector cells in general as well as in allergic inflammation andin the defence against helminthic parasites and bacteria. Two major populations, withdifferences in tissue distribution, have been identified; connective tissue mast cells andmucosal mast cells. READ MORE

  5. 3. Strategies to improve and balance the expression levels of recombinant proteins in mammalian cell lines

    Author : Mona Moradi Barzadd; Johan Rockberg; Alan Dickson; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CHO; HEK293; Aggregation; Bispecific; Cancer assay; Cell line engineering; sulfatase; biologics; transcriptomic; Biotechnology; Bioteknologi;

    Abstract : Proteins are the building blocks of all living organisms enabling us to function and survive. There are more than 100,000 different proteins in the human body performing a variety of vital tasks. READ MORE

  6. 4. Restricted antigen recognition in B cell chronic lymphocytic leukemia

    Author : Anna Lanemo Myhrinder; Anders Rosén; Linköpings universitet; []
    Keywords : Chronic lymphocytic leukemia; auto antigens; CLL cell lines; MEDICINE; MEDICIN;

    Abstract : Chronic lymphocytic leukemia (CLL) cells are considered to be derived from antigen-exposed B cells. To further explore the antigen-driven selection behind the leukemogenesis of CLL, we performed immunoglobulin (Ig) specificity screening of 7 CLL cell lines and 23 primary CLL clones from patient peripheral blood. READ MORE

  7. 5. Oxidative stress on mammalian cell cultures during recombinant protein expression

    Author : Tomás McKenna; Carl-Fredrik Mandenius; Linköpings universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP;

    Abstract : When the cell is under stress arising from oxidation, heat, infection, toxic contamination or any other stressful condition, proteins may unfold and expose residues in their structure that under normal physiological conditions are hidden and shielded from chemical reactions.In this licentiate thesis the effects of general oxidative stress on the production of recombinant protein by mammalian cells are considered. READ MORE