Search for dissertations about: "regulatory sequence analysis"

Showing result 1 - 5 of 67 swedish dissertations containing the words regulatory sequence analysis.

  2. 1. Genetic and Genomic Analysis of DNA Sequence Variation

    Author : Per Erik Lundmark; Ann-Christine Syvänen; Karl Michaelsson; Gert-Jan B. van Ommen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SNP; NPC1; association study; allele specific expression; tagSNP; non-coding RNA; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; Molekylär medicin; Molecular Medicine;

    Abstract : The studies in this thesis describe the application of genotyping and allele specific expression analysis to genetic studies. The role of the gene NPC1 in Triglyceride metabolism was explored in mouse models and in humans on the population level in study I. READ MORE

  4. 2. A genomic approach to smooth muscle differentiation and diversity

    Author : Sven Nelander; Göteborgs universitet; []
    Keywords : Keywords: smooth muscle; phenotype; transcriptional regulation; differentiation; transcriptome; microarray; computational prediction; co-expression network; regulatory sequence analysis; gene module; gene battery;

    Abstract : Smooth muscle cells (SMCs) are a broad class of contractile cells that are found in a number of organs systems, including the vasculature, the urogenital system, the bronchi and the gastrointestinal tract. The two main functions exerted by SMCs are to provide contractile force and to synthesize structural components of the extracellular matrix. READ MORE

  5. 3. On diverse biophysical aspects of genetics : from the action of regulators to the characterization of transcripts

    Author : Aymeric Fouquier D´Hérouel; Erik Aurell; Felix Ritort; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; transcription regulation; regulatory motifs; binding affinity; genetic interactions; secondary structure; sequence repeats; transcript characterization; Biological physics; Biologisk fysik;

    Abstract : Genetics is among the most rewarding fields of biology for the theoretically inclined, offering both room and need for modeling approaches in the light of an abundance of experimental data of different kinds. Many aspects of the field are today understood in terms of physical and chemical models, joined by information theoretical descriptions. READ MORE

  6. 4. Functional analysis of genetic risk markers

    Author : Jesper Robert Gådin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Regulatory variants are the main factors responsible for genetic predisposition to how e.g. humans react differently to the environment. READ MORE

  7. 5. Gene regulatory evolution in flycatchers: statistical approaches for the analysis of allele-specific expression

    Author : Mi Wang; Hans Ellegren; Christopher Wheat; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ASE; gene expression evolution; bayesian; RPASE; flycatcher.; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

    Abstract : Understanding the molecular mechanisms underlying evolutionary changes in gene expression is a major research topic in biology. While a powerful approach to study this is the analysis of allele-specific expression (ASE), most of previously published methods can only be applied to lab organisms. READ MORE