Search for dissertations about: "relapse clinical trials"
Showing result 1 - 5 of 30 swedish dissertations containing the words relapse clinical trials.
-
1. Treatment failure in pediatric acute myeloid leukemia: factors associated with frequency and outcome of resistant disease and relapse
Abstract : Although the prognosis for childhood acute myeloid leukemia (AML) has improved over the last decades to a survival of over 70%, still 30-40 % relapse and 5-10% experience resistant disease with poor prognosis. The aim of this thesis was to perform a detailed analysis of disease characteristics and treatment in children with relapsed and resistant AML to provide means to improve prognosis. READ MORE
-
2. Studies on new pharmacological treatments for alcohol dependence - and the importance of objective markers of alcohol consumption
Abstract : This thesis will guide you through three randomized controlled trials (RCT) on three pharmacotherapies for alcohol dependence; the antidepressant drug mirtazapine, the smoking cessation drug varenicline and the glycine-uptake inhibitor Org 25935. The mirtazapine study was an investigator initiated single-center harm-reduction study with alcohol consumption measured by self-report in a diary as main outcome. READ MORE
-
3. Measurable residual disease and clonal evolution in acute myeloid leukemia with focus on NPM1-mutations
Abstract : Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults, with mutations in the NPM1 gene occurring in almost one third of all cases. The ability to detect residual leukemia below the resolution of conventional microscopy is crucial for evaluation of relapse risk after therapy. READ MORE
-
4. EM Estimation in Phase Type Models
Abstract : This thesis consists of four articles whose theme in common is the class of phase type distributions. In the first article an EM algorithm is presented to estimate the parameters of a phase type distribution of fixed order. Also, it is shown that the algorithm can be used to approximate other continuous distributions by phase type distributions. READ MORE
-
5. Orthodontic retention : studies of retention capacity, cost-effectiveness and long-term stability
Abstract : Retention strategies, cost-effectiveness and long-term stability oftreatment outcome are essential aspects of orthodontic treatmentplanning.The overall aim of this thesis was to compare and evaluate threedifferent retention strategies, with special reference to short- andlong-term clinical stability and cost-effectiveness. READ MORE