Search for dissertations about: "repair inhibition"
Showing result 1 - 5 of 96 swedish dissertations containing the words repair inhibition.
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1. Biophysical investigations of ribonucleotide reductase : Activation and inhibition mechanisms
Abstract : Ribonucleotide reductase (RNR) is the enzyme responsible for de novo synthesis of deoxyribonucleotides, needed for both synthesis and repair of cellular DNA. The RNRs known so far are divided into three distinct classes; I, II and III. The conventional class I enzyme is composed of two separate subunits. READ MORE
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2. Post-translational modifications in DNA base excision repair : The roles of CK2 and PARP-1
Abstract : Base lesions and DNA single-strand breaks (SSBs) are very common types of DNA damage. The base excision repair (BER) and single-strand break repair (SSBR) machineries both require a succession of enzymatic events in order to remove these types of endogenous lesions and to restore the DNA. READ MORE
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3. ARCON in experimental and clinical radiotherapy
Abstract : xHypoxia and repopulation of tumour clonogens are two important determinants of treatment outcome in radiotherapy. In general clinical evidence indicates that loco-regional control may be reduced with long overall treatment times and for tumours with low pre-treatment levels of oxygen. READ MORE
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4. Cellular Origin and Development of Glioma
Abstract : Gliomas are the most common primary tumors of the central nervous system believed to arise from glial cells. Invasive growth and inherent propensity for malignant progression make gliomas incurable despite extensive treatment. READ MORE
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5. Targeting DNA repair pathways for cancer therapy
Abstract : Accumulation of genomic mutations is the consequence of failure in DNA repair as well as increased exposure to endogenous/environmental mutagens. DNA repair pathways safeguard the human genome from such mutagens, and thereby suppress the multi-step process of carcinogenesis. READ MORE