Search for dissertations about: "repeated time-to-event"
Found 5 swedish dissertations containing the words repeated time-to-event.
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1. Mixed Effects Modeling of Deterministic and Stochastic Dynamical Systems - Methods and Applications in Drug Development
Abstract : Mathematical models based on ordinary differential equations (ODEs) are commonly used for describing the evolution of a system over time. In drug development, pharmacokinetic (PK) and pharmacodynamic (PD) models are used to characterize the exposure and effect of drugs. READ MORE
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2. Pharmacometric Methods and Novel Models for Discrete Data
Abstract : Pharmacodynamic processes and disease progression are increasingly characterized with pharmacometric models. However, modelling options for discrete-type responses remain limited, although these response variables are commonly encountered clinical endpoints. Types of data defined as discrete data are generally ordinal, e.g. READ MORE
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3. Benefits of Pharmacometric Model-Based Design and Analysis of Clinical Trials
Abstract : Quantitative pharmacokinetic-pharmacodynamic and disease progression models are the core of the science of pharmacometrics which has been identified as one of the strategies that can make drug development more effective. To adequately develop and utilize these models one needs to carefully consider the nature of the data, choice of appropriate estimation methods, model evaluation strategies, and, most importantly, the intended use of the model. READ MORE
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4. Generalized survival models as a tool for medical research
Abstract : In medical research, many studies with the time-to-event outcomes investigate the effect of an exposure (or treatment) on patients’ survival. For the analysis of time-to-event or survival data, model-based approaches have been commonly applied. READ MORE
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5. Oral eflornithine treatment of late-stage human African trypanosomiasis
Abstract : Human African trypanosomiasis is a fatal disease unless treated. It is a parasitic vector borne disease endemic in sub-Saharan African countries. Eflornithine is a recommended treatment for gambiense human African trypanosomiasis (g-HAT) in the later disease stage when the parasites have infected the central nervous system. READ MORE