Search for dissertations about: "residual error modeling"

Showing result 1 - 5 of 10 swedish dissertations containing the words residual error modeling.

  2. 1. Improved Methods for Pharmacometric Model-Based Decision-Making in Clinical Drug Development

    Author : Anne-Gaëlle Dosne; Mats O. Karlsson; Rik Schoemaker; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; nonlinear mixed-effects models; confirmatory trials; residual error modeling; parameter uncertainty; sampling importance resampling; model-averaging; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Pharmacometric model-based analysis using nonlinear mixed-effects models (NLMEM) has to date mainly been applied to learning activities in drug development. However, such analyses can also serve as the primary analysis in confirmatory studies, which is expected to bring higher power than traditional analysis methods, among other advantages. READ MORE

  4. 2. Environmental Modelling : Learning from Uncertainty

    Author : John M. Juston; Per-Erik Jansson; Jens Christian Refsgaard; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Models; data; error; uncertainty; hydrology; soil carbon; wetlands; phosphorus;

    Abstract : Environmental models are important tools; however uncertainty is pervasive in the modeling process.   Current research has shown that under­standing and representing these uncertainties is critical when decisions are expected to be made from the modeling results. READ MORE

  5. 3. On Error-Controlled Numerical Model Reduction for Linear Transient FE² Analysis

    Author : Fredrik Ekre; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; computational homogenization; error estimation; model reduction;

    Abstract : Multiscale modeling is of high interest in the engineering community due to its ability to capture the overall response, while still accounting for processes and structures on underlying fine scales. One standard approach to multiscale modeling is the so-called FE² procedure, where the classic constitutive relation is replaced by a boundary value problem on a Representative Volume Element (RVE) comprising the underlying microscale features. READ MORE

  6. 4. Numerical Model Reduction and Error Control for Computational Homogenization of Transient Problems

    Author : Fredrik Ekre; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; model reduction; error estimation; computational homogenization;

    Abstract : Multiscale modeling is a class of methods useful for numerical simulation of mechanics, in particular, when the microstructure of a material is of importance. The main advantage is the ability to capture the overall response, and, at the same time, account for processes and structures on the underlying fine scales. READ MORE

  7. 5. Finite Element Modeling of Contact Problems

    Author : Asim Rashid; Peter Hansbo; Niclas Strömberg; Anders Klarbring; Anders Eriksson; Linköpings universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Abstract : Contact is the principal way load is transferred to a body. The study of stresses and deformations arising due to contact interaction of solid bodies is thus of paramount importance in many engineering applications. In this work, problems involving contact interactions are investigated using finite element modeling. READ MORE