Search for dissertations about: "resistance mechanism"

Showing result 1 - 5 of 558 swedish dissertations containing the words resistance mechanism.

  2. 1. Multi-Resistance Plasmids : Fitness Costs, Dynamics and Evolution

    Author : Fredrika Rajer; Linus Sandegren; Pål Jarle Johnsen; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; multi-resistance plasmids; evolution; fitness cost; dynamics; escherichia coli; ESBL; gene amplification; β-lactamase inhibitor; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

    Abstract : Antibiotic resistance is an escalating problem, not only due to less desirable treatment options and outcome, but also due to the economic burden to health care caused by resistant pathogens. Since the process of developing new antibiotics is slow, we need to carefully consider the usage of the antibiotics still available. READ MORE

  4. 2. Pharmacology and resistance mechanisms of nucleoside analogues and topoisomerase II interactive agents : studies on human leukemia cells with a focus on cross-resistance

    Author : Kourosh Lotfi; Rolf Larsson; Linköpings universitet; []
    Keywords : Nucleoside analogue; cross-resistance; multidrug resistance; deoxycytidine kinase; leukemia; anthracyclines; P-glycoprotein; MEDICINE; MEDICIN;

    Abstract : The purpose of this thesis was to elucidate mechanisms of action and resistance of clinically relevant nucleoside analogues and topoisomerase interactive agents in human leukemia cell lines and leukernia cells isolated from peripheral blood of leukemia patients. Interactions and cross-resistance patterns of these different cytotoxic drug families were also studied since these drugs are usually administrated in combination in the clinic. READ MORE

  5. 3. Antimicrobial peptides in the treatment of infectious and inflammatory conditions : Preclinical studies of mechanism of action, efficacy, and safety

    Author : Camilla Björn; RISE; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antimicrobial peptides; AMPs; innate immunity; infection; inflammation; mechanism of action; efficacy; safety; antimicrobial resistance; antibiotic resistance; Antimicrobial peptides; AMPs; innate immunity; infection; inflammation; mechanism of action; efficacy; safety; antimicrobial resistance; antibiotic resistance;

    Abstract : The rapid emergence of antibiotic-resistant microbes worldwide and the urgent need of new antimicrobial agents have stimulated interest in antimicrobial peptides (AMPs) as new therapeutics for treatment of infectious diseases. AMPs are present in all living species and constitute an important part of the innate immune system in multicellular organisms, including humans. READ MORE

  6. 4. ASNA1 and cisplatin resistance : studies in C. elegans and in human tumor cells

    Author : Oskar Hemmingsson; Peter Naredi; Mef Nilbert; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ASNA1; Cisplatin; C. elegans; Drug resistance; Apoptosis; Surgery; Kirurgi; Oncology; Onkologi; Surgery; kirurgi; Oncology; onkologi; cellforskning; cell research;

    Abstract : Platinum based chemotherapy is widely used to treat cancer. Cisplatin (diamminedichloroplatinum) combination treatments provide cure for metastatic testicular cancer and prolong survival for patients suffering from ovarian, head and neck, bladder and non small cell lung cancer. READ MORE

  7. 5. Biomechanical and neural aspects of eccentric and concentric muscle performance in stroke subjects : Implications for resistance training

    Author : Mattias Hedlund; Britta Lindström; Peter Sojka; Ronnie Lundström; Carl-Johan Olsson; Jan Lexell; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fMRI; Isokinetic; Motor imagery; Muscular strength; Resistance training; Neurological rehabilitation;

    Abstract : Muscle weakness is one of the major causes of post-stroke disability. Stroke rehabilitation programs now often incorporate the same type of resistance training that is used for healthy subjects; however, the training effects induced from these training strategies are often limited for stroke patients. READ MORE