Search for dissertations about: "retinoic acid."

Showing result 1 - 5 of 113 swedish dissertations containing the words retinoic acid..

  1. 1. Effects of retinoic acid in the mouse olfactory sensory systems

    University dissertation from Umeå : Molekylärbiologi (Medicinska fakulteten)

    Author : Maria Hörnberg; Umeå universitet.; [2007]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; olfactory; retinoic acid; neuron survival; NATURAL SCIENCES Chemistry Biochemistry Molecular biology; NATURVETENSKAP Kemi Biokemi Molekylärbiologi;

    Abstract : A common characteristic in neurodegenerative diseases of the brain is death of specific neuronal populations. The lack of neuron proliferation and axon extension in most parts of the central nervous system leads to chronic loss of neurons in the case of injury or disease. READ MORE

  2. 2. CYP26B1 as regulator of retinoic acid in vascular cells and atherosclerotic lesions

    University dissertation from Örebro : Örebro universitet

    Author : Ali Ateia Elmabsout; Örebro universitet.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CYP26B1; alternative splice; vascular cells; atherosclerosis; alltrans-retinoic acid; gene polymorphism; inflammation; statins; Medicin; Medicine;

    Abstract : Cardiovascular disease (CVD), currently the most common cause of morbidity and mortality worldwide, is caused mainly by atherosclerosis. Atherosclerosis is a chronic multifocal, immunoinflammatory, fibroproliferative disease of medium and large arteries. READ MORE

  3. 3. Retinoic Acid Metabolism Blocking Agents and the Skin In vivo and in vitro Studies of the Effects on Normal and Diseased Human Epidermis

    University dissertation from Uppsala : Universitetsbiblioteket

    Author : Elizabeth Pavez Loriè; Uppsala universitet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CYP; CYP26; retinoids; vitamin A; RAMBA; metabolism; keratinocyte; epidermis; retinoid regulated genes; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Dermatology and venerology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Dermatologi och venerologi;

    Abstract : Retinoic Acid Metabolism Blocking Agents (RAMBAs) increase the endogenous levels of all-trans retinoic acid (RA) by inhibiting CYP26 enzymes. Thus they are believed to mimic the effects of retinoid treatment. Their mechanism of action and effects on vitamin A metabolism in keratinocytes are however uncertain. READ MORE

  4. 4. Effects of ellagic acid in human neuroblastoma cells

    University dissertation from Karlstad : Karlstads universitet

    Author : Christina Fjæraa Alfredsson; Karlstads universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; polyphenols; ellagic acid; neuroblastoma; SH-SY5Y cells; differentiation; proliferation; apoptosis; cell adhesion; Biomedical Sciences; Biomedicinsk vetenskap;

    Abstract : A diet rich in polyphenols has been proposed to have beneficial health effects and to reduce risk of disease. Ellagic acid, a polyphenol common in red berries and pomegranates, has potential anti-tumorigenic effects that make it interesting to further study in different cancer cell systems. READ MORE

  5. 5. Activity-regulated retinoic acid signaling in olfactory sensory neurons

    University dissertation from Umeå : Umeå Universitet

    Author : Hande Login; Umeå universitet.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mouse olfactory system; RA; neuronal activity; CNG; Cyp26B1; BACE1; Kirrel-2; molekylärbiologi; Molecular Biology;

    Abstract : The aim of the studies included in the thesis is to better understand the interplay between neuronal activity-dependent gene regulation and the bioactive vitamin A metabolite all-trans-retinoic acid (RA) during postnatal development, refinement and maintenance of precise neuronal connectivity using the olfactory sensory neuron (OSN) in the olfactory epithelium (OE) of genetically modified mice as a model. We show that:Inhibition of RA receptor (RAR)-mediated transcription in OSNs reduces expression of the olfactory cyclic nucleotide-gated (CNG) ion channel, which is required for odorant receptor (OR)-mediated stimulus transduction. READ MORE