Search for dissertations about: "runt domain"
Showing result 1 - 5 of 29 swedish dissertations containing the words runt domain.
-
1. Structure-function relationships of the human Runx1 transcription factor
Abstract : Runx transcription factors contain a DNA-binding andtransactivating α-subunit and a β-subunit (CBFβ)that serves to increase the DNA binding affinity of theα-subunit. The DNA binding domain of Runx proteins isnamed the Runt homology domain (RD) after its strong sequencehomology to theDrosophilaprotein Runt. READ MORE
-
2. The hematopoietic transcription factor RUNX1 : a structural view
Abstract : The malfunction of the transcriptional regulator RUNX1 is the major cause of several variants of acute human leukemias and its normal function is to regulate the development of the blood system in concert with other transcriptional co-regulators. RUNX1 belongs to a conserved family of heterodimeric transcription factors that share a conserved DNA binding domain, the Runt domain (RD), named after the first member of this group – Runt - found in Drosophila melanogaster. READ MORE
-
3. NMR STUDIES ON STRUCTURE AND DYNAMICS OF TWO-DOMAIN PROTEINS
Abstract : The general objective of the present thesis work was to examine 3-dimensional structure as well as the motional properties of two different types of two-domain proteins by solution-state NMR. One of the major tasks of this thesis work was to investigate the domain orientation of these molecules by employing residual dipolar couplings (RDC) which can be used as orientational restraints for increasing the accuracy of protein structures determined by NMR. READ MORE
-
4. The Jovian Plasma Dynamics and Composition Analyzer (JDC) for ESA's JUICE Mission
Abstract : This dissertation covers the development and calibration of the Jovian plasma Dynamics and Composition analyzer (JDC). JDC is together with five other sensors a part of the Particle Environment Package (PEP), one of the payloads of the European Space Agency's JUpiter ICy moons Explorer (JUICE) mission. READ MORE
-
5. Fibromodulin and chondroadherin in connective tissue homeostasis
Abstract : Connective tissue contains a prominent extracellular matrix (ECM), which provides for physiological and mechanical properties. Intra- and inter-molecular interactions between proteins in this ECM provide for the formation of molecular networks. These interactions determine the shape of the tissue as well as cell behavior. READ MORE