Search for dissertations about: "sLex"

Showing result 1 - 5 of 13 swedish dissertations containing the word sLex.

  2. 1. Synthetic analogs of sialyl Lewis x

    Author : Ulf Ellervik; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; stereoselective synthesis; regioselective synthesis; lactam analogs; lactone; Selectin; Sialyl Lewis x; SLex; Organic chemistry; Organisk kemi;

    Abstract : The sialyl Lewis x (SLex) tetrasaccharide is the smallest recognizable ligand for selectins. The selectins constitute a vital part of the inflammatory cascade for recruitment of leukocytes to a site of tissue damage or microbial infection. READ MORE

  4. 2. Helicobacter pylori : molecular mechanisms for variable adherence properties

    Author : Anna Vallström; Anna Arnqvist; Kristian Riesbeck; Umeå universitet; []
    Keywords : H. pylori; adherence; BabA; SabA; Leb; sLex; phase variation; recombination; vesicles;

    Abstract : More than half of all people worldwide are infected with H. pylori. The infection always cause a gastric inflammation that may develop into peptic ulcer disease or gastric cancer. Attachment proteins, adhesins, mediate specific adherence of H. READ MORE

  5. 3. Studies on the biosynthesis of ABH and Lewis epitopes on O-glycans

    Author : Jonas Löfling; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Fucose; Lewis antigen; Blood group ABH; biosynthesis;

    Abstract : ABH and Lewis antigens are carbohydrate epitopes (glycans) found on a wide variety of cell surfaces. They are involved in many biological processes, e.g transplantation rejection, bacterial and viral adhesion, cell-cell communication and metastasis. The in vivo synthesis of glycans is mediated by glycosyltransferases (GTs). READ MORE

  6. 4. Herpesvirus-induced glycans: Selectin ligands and related structures on the surface of the infected cell

    Author : Rickard Nordén; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Virology; Glycobiology; Herpesvirus; Selectin ligand;

    Abstract : Human herpesviruses are usually acquired early in life and are widely distributed in the population. A common feature of all human herpesviruses is that they persist in the host after the primary infection. READ MORE

  7. 5. Herpesvirus-induced expression of sLe(x) and related O-linked glycans in the infected cell

    Author : Kristina Nyström; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HSV-1; CMV; VZV; O-linked glycans; Lewis antigens; ICP0;

    Abstract : Lewis antigens constitute a family of fucosylated carbohydrate antigens (glycotopes), involved in leukocyte homing and related immunological phenomena. These glycotopes are only expressed restrictedly in normal cells, but are induced at appropriate occasions. It is well established that many tumors ?hijack? Lewis glycotopes for e.g. READ MORE