Search for dissertations about: "secondary metabolite"

Showing result 1 - 5 of 32 swedish dissertations containing the words secondary metabolite.

  2. 1. Systems Biology of the Secondary Metabolism in Filamentous Fungi

    Author : Jens Christian Froslev Nielsen; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; genomics; systems biology; secondary metabolites; antibiotics; Next-generation sequencing; secondary metabolism; filamentous fungi; cell factories; Penicillium;

    Abstract : Filamentous fungi constitute a rich reservoir of pharmaceutically relevant bioactive small molecules. These compounds, commonly referred to as secondary metabolites, are widely used as antibiotics for the treatment of microbial infections, but also as other pharmaceuticals such as immunosuppressors, cholesterol lowering agents and anticancer drugs. READ MORE

  4. 2. Bioactive Compounds in the Chemical Defence of Marine Sponges : Structure-Activity Relationships and Pharmacological Targets

    Author : Erik Hedner; Lars Bohlin; Per R Jonsson; Raffaele Riccio; Uppsala universitet; []
    Keywords : Pharmacognosy; 5-hydroxytryptamine; agelasine; agelasimine; antibacterial; antifouling; barettin; bromobenzisoxazolone barettin; cytotoxic; marine; secondary metabolite; sponge; Farmakognosi; Agelas; Geodia barretti;

    Abstract : Marine invertebrates, in particular sponges, represent a source of a wide range of secondary metabolites, many of which have been attributed various defensive capabilities against environmental stress factors. In this thesis sponge-derived low-molecular peptide-like compounds and associated analogs are investigated for bioactivity and pharmacological targets. READ MORE

  5. 3. Analysis of Secondary Metabolites from Aspergillus fumigatus and Penicillium nalgiovense : Antimicrobial Compounds from Filamentous Fungi Isolated from Extreme Environments

    Author : Stefan Svahn; Lars Bohlin; Björn Olsen; Ulf Göransson; Erja Chryssanthou; Douglas Kinghorn; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Aspergillus fumigatus; Penicillium nalgiovense; secondary metabolites; invasive aspergillosis; elicitation; gliotoxin; bis methyl gliotoxin; amphotericin B; Pharmacognosy; Farmakognosi;

    Abstract : This thesis describes the cultivation and extraction of filamentous fungi isolated from extreme environments in the search for new antibiotic compounds. Filamentous fungi are a rich source of medicines including antibiotics, and it is believed that many currently unknown fungal species and bioactive fungal metabolites remain to be discovered. READ MORE

  6. 4. Role of mycorrhiza symbiosis and phosphorus nutrition in plant growth, photosynthesis and secondary metabolism

    Author : Lisa Adolfsson; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Arbuscular mycorrhiza; Plant; Phosphorus; Secondary metabolism; Photosynthesis;

    Abstract : Inorganic phosphorus (Pi) is an important and often limiting nutrient for plants. Large amounts of Pi fertilizers derived from non-renewable rock phosphorus, are used in agriculture. These are applied in excess but crops take up only a small amount of Pi; the residual Pi ends up in water systems where it causes problems with eutrophication. READ MORE

  7. 5. Elicitor-induced formation of secondary products in plant cell cultures. Production of benzophenanthridine alkaloids in Eschscholtzia californica Cham. and hydroxycinnamic acid tyramides in Nicotiana glutinosa L

    Author : Mirza Villegas; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; macarpine; chelerythrine; sanguinarine; benzophenanthridine alkaloids; Nicotiana glutinosa; Eschscholtzia californica; secondary metabolites; Key words elicitors; immobilisation; hydroxycinnamoyltyramides.; Plant biochemistry; Växtbiokemi;

    Abstract : Biotic and abiotic elicitors induce biosynthesis of secondary metabolites (phytoalexins) as a defense against pathogenic organisms in plants. The use of cell suspension cultures in combination with elicitors offer excellent experimental model systems for studies on various elicitor-induced responses of plant tissues. READ MORE