Search for dissertations about: "secretase"
Showing result 1 - 5 of 61 swedish dissertations containing the word secretase.
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1. Proteolytic processing of the Alzheimer APP protein family during neuronal differentiation
Abstract : Increased amyloid-β (Aβ) load in the brain, neurite degeneration, neuronal loss, and decreased levels of several neurotrophins are among the characteristics of Alzheimer’s disease (AD). Generation of Aβ occurs when the amyloid precursor protein (APP) is proteolytically processed by β- and γ-secretases in the amyloidogenic pathway. READ MORE
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2. Studies on gamma-secretase activity and products
Abstract : gamma-Secretase is a transmembrane aspartyl protease involved in processing of a multitude of functionally diverse substrates within their transmembrane domains. gamma-Secretase cleavage of the amyloid precursor protein (APP) generates the APP intracellular domain (AICD) and the amyloid beta-peptide (Abeta). READ MORE
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3. Identification and investigation of gamma-secretase associated proteins from brain
Abstract : Alzheimer disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. The pathological hallmarks in the AD brain are extracellular deposition of amyloid plaques, mainly composed of the amyloid β-peptide (Aβ), and intracellular neurofibrillary tangles made of hyperphosphorylated tau. READ MORE
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4. A study of b-secretase cleaved Alzheimer amyloid precursor protein
Abstract : Alzheimer's disease (AD) is characterized by the degeneration and loss of neurons, intracellular neurofibrillary tangles and the accumulation of extracellular senile plaques consisting mainly of beta-amyloid (A-beta). A-beta is generated from the amyloid precursor protein (APP) through sequential cleavage by proteases P- and gamma-secretase. READ MORE
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5. The amyloid-β precursor protein (APP) and its adaptor protein Fe65 : Two key players in Alzheimer’s disease
Abstract : Alzheimer’s disease (AD) is a neurodegenerative disease characterized by the abnormal accumulation and aggregation of amyloid beta (Aβ) peptides within the brain. Generation of Aβ occur when the amyloid-beta precursor protein (APP) is proteolytically processed by β- and then γ-secretase in the amyloidogenic pathway. READ MORE