Search for dissertations about: "self-administration"

Showing result 1 - 5 of 19 swedish dissertations containing the word self-administration.

  2. 1. Neurobiological Consequences of Social Conditions and Alcohol Exposure in Adolescent rats

    Author : Linnea Granholm; Ingrid Nylander; Anne-Lie Svensson; Erika Roman; Maria Ellgren; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adolescence; alcohol; amphetamine; dopamine; dorsal striatum; dynorphin; endogenous opi- oids; enkephalin; high-speed chronoamperometry; housing conditions; rats; nociceptin orphanin FQ; radi- oimmunoassay; self-administration; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Adolescence represents a time of extensive reorganisation and maturation of brain circuits involved in emotions, motivation and cognition and it is a period particular sensitive for external stimuli. External stimuli can be both socio-environmental factors and exposure to exogenous compounds such as drugs of abuse (e.g. alcohol). READ MORE

  4. 2. Stress, Drugs and Neuroscience : Neurobiological Effects of Social Stressors and Drug Exposure in Young and Adolescent Rats

    Author : Linnea Granholm; Ingrid Nylander; Erika Roman; Anne-Lie Svensson; Maria Ellgren; Annika Thorsell; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adolescence; alcohol exposure; amphetamine; beta-endorphin; dopamine; dynorphin; early life; endogenous opioids; enkephalin; gene expression; high-speed chronoamperometry; nociceptin orphanin FQ; radioimmunoassay; self-administration; social stress; voluntary alcohol intake; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Experiences early in life or during adolescence modulate neuronal networks in the immature brain and consequently lay the foundation for future susceptibility or resilience towards psychiatric disorders. The objective in this thesis is to understand, in part, how the surrounding environment shapes the brain of a young individual. READ MORE

  5. 3. Across Borders : A Histological and Physiological Study of the Subthalamic Nucleus in Reward and Movement

    Author : Nadine Schweizer; Åsa Wallén-Mackenzie; Dai Stephens; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; subthalamic nucleus; STN; basal ganglia; locomotion; hyperlocomotion; rearing; ventral tegmental area; VTA; dopamine; glutamate; vesicular glutamate transporter 2; Vglut2; Parkinson s disease; deep brain stimulation; subpopulation; conditional knock-out; optogenetic; co-expression; in situ hybridization; self-administration; reward behavior; mouse genetics;

    Abstract : The basal ganglia are the key circuitry controlling movement and reward behavior. Both locomotion and reward-related behavior are also modified by dopaminergic input from the substantia nigra and the ventral tegmental area (VTA). READ MORE

  6. 4. Factors affecting alcohol self-administration : learning, environmental and genetic influences on behaviour

    Author : Christopher Pickering; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ethanol; operant self-administration; addiction; reward; learning; lever press response; context; environmental cue; novelty; stress; glutamate; GABA; noradrenaline; PCR; gene expression; functional genomics; prefrontal cortex; hippocampus; amygdala;

    Abstract : Alcoholism is a serious problem for society and is a very difficult disease to treat clinically. Often, the addict has periods of abstinence from alcohol followed by relapse to drinking and this cycle of use/non-use can repeat over many years. READ MORE

  7. 5. Functional Analysis of the Vesicular Glutamate Transporter 2 in Specific Neuronal Circuits of the Brain

    Author : Karin Nordenankar; Åsa Wallén-Mackenzie; Rainer Spanagel; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Addiction; amphetamine; affective behaviour; cocaine; cognitive behaviour; conditional knockout mouse; dopamine; operant self-administration; reward system; schizophrenia; Neuroscience; Neurovetenskap;

    Abstract : A key issue in neuroscience is to determine the connection between neuronal circuits and behaviour. In the adult brain, all neuronal circuits include a glutamatergic component. READ MORE