Search for dissertations about: "self-renewal"

Showing result 1 - 5 of 89 swedish dissertations containing the word self-renewal.

  2. 1. Molecular and cellular analysis of Lhx2 function in hematopoietic stem cells

    Author : Karin Richter; Leif Carlsson; Andrew Elefanty; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Hematopoietic stem cells; Lhx2; cell lines; self renewal; SCF; IL-6; chronic myeloproliferative disorder; global gene expression analysis; Molecular biology; Molekylärbiologi;

    Abstract : The formation of blood, hematopoiesis, is a dynamic process originating from a small number of hematopoietic stem cells (HSCs). To sustain hematopoiesis throughout life HSCs have the unique capacity to differentiate into all mature hematopoietic lineages as well as generating more HSCs by a mechanism referred to as self-renewal. READ MORE

  4. 2. Identification and Characterization of Stem Cells in Preleukemia and Leukemia

    Author : Lars Nilsson; Stamcellscentrum (SCC); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Haematology; extracellulära vätskor; Hematologi; Philadelphia chromosome; acute lymphoblastic leukemia; polycytemia vera; 5q- syndrome; myelodysplastic syndromes; self-renewal; preleukemia; Hematopoietic stem cells; leukemic stem cells; extracellular fluids;

    Abstract : Hematopoietic stem cells (HSCs) are responsible for the daily and life long production of large numbers of mature blood cells through highly regulated self-renewal and multilineage capabilities. Leukemias on the other hand, are characterized by a clonal, dysregulated, lineage skewed proliferation and impaired differentiation as the result of multiple accumulated genetic events. READ MORE

  5. 3. Identification of Unique Hematopoietic Stem Cell Properties

    Author : Jens Nygren; Lunds universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Cardiovascular system; Hematologi; extracellulära vätskor; Haematology; extracellular fluids; cell cycle; fusion; transdifferentiation; plasticity; Medicine human and vertebrates ; Medicin människa och djur ; quiescence; hematopoietic stem cell; self-renewal;

    Abstract : Hematopoietic stem cells (HSC) are sufficient and required for life long production of all blood cell lineages. Steady state HSCs are largely quiescent and we demonstrate that the kinetics of HSC cell cycling are slower compared to more committed progenitor cells also during expansion and self-renewal ex vivo and in physiological conditions. READ MORE

  6. 4. Live and Let Die : Critical regulation of survival in normal and malignant hematopoietic stem and progenitor cells

    Author : Pernilla Eliasson; Jan-Ingvar Jönsson; Mikael Sigvardsson; Urban Gullberg; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hematopoietic stem cells; hypoxia; self-renewal; survival; acute myeloid leukemia; FLT3; Cell and molecular biology; Cell- och molekylärbiologi; Haematology; Hematologi;

    Abstract : The hematopoietic stem cell (HSC) is characterized by its ability to self-renew and produce all mature blood cells throughout the life of an organism. This is tightly regulated to maintain a balance between survival, proliferation, and differentiation. READ MORE

  7. 5. The Role of Lhx2 During Organogenesis : - Analysis of the Hepatic, Hematopoietic and Olfactory Systems

    Author : Åsa Kolterud; Leif Carlsson; Stefan Thor; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; LIM-homeobox gene; Lhx2; fetal liver; hepatic stellate cells; hematopoietic stem cells; septum transversum; self-renewal; odorant receptor genes; olfactory epithelium; olfactory sensory neuron; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; molekylärbiologi; Molecular Biology;

    Abstract : During embryonic development a variety of tissues and organs such as the lung, eye, and kidney are being formed. The generation of functional organs is regulated by reciprocal cell-cell interactions. Via the secretion of soluble molecules one type of cells affect the fate of their neighboring cells. READ MORE