Search for dissertations about: "serca"

Showing result 1 - 5 of 12 swedish dissertations containing the word serca.

  2. 1. Human muscle spindles : complex morphology and structural organisation

    Author : Jing-Xia Liu; William K. Ovalle; Umeå universitet; []
    Keywords : human; muscle spindle; intrafusal fiber; aging; biceps brachii; deep muscles of the neck; MyHC; mATPase; SERCA; anatomi; Human Anatomy;

    Abstract : Muscle spindles are skeletal muscle mechanoreceptors that mediate the stretch reflex and provide axial and limb position information to the central nervous system. They have been proposed to play a major role in the pathophysiology of muscle pain. READ MORE

  4. 2. Human extraocular muscles : molecular diversity of a unique muscle allotype

    Author : Daniel Kjellgren; Fatima Pedrosa-Domellöf; Lars-Erik Thornell; Lillemor Wachtmeister; John Porter; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ophtalmology; extraocular; muscle; myosin; protein c; laminin; serca; immunocytochemistry; human; Oftalmiatrik; Ophtalmology; Oftalmologi; oftalmiatrik; Ophtalmology;

    Abstract : Introduction: The extraocular muscles (EOMs) are considered a separate class of skeletal muscle, allotype. Myosin is the major contractile protein in muscle. The myosin heavy chain (MyHC) isoforms are the best molecular markers of functional heterogeneity of muscle fibers. READ MORE

  5. 3. Determining the effects of regulatory parameters on the structural dynamics of P-type ATPase membrane transporters

    Author : Fredrik Orädd; Magnus Andersson; Magnus Wolf-Watz; Marco Cammarata; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; protein dynamics; regulation; time-resolved x-ray solution scattering; MD simulation; membrane protein; P-type ATPase; SERCA; CopA; HMA4; adenylate kinase; Physical Chemistry; fysikalisk kemi;

    Abstract : Proteins are macromolecular machines with roles in all cellular activities and structures. The functional properties of each protein is the result of its combination of 3D-structure and inherent dynamics, and a wealth of structural and dynamic mechanisms have evolved to regulate protein activity. READ MORE

  6. 4. ATP Dynamics in Pancreatic α- and β-cells

    Author : Jia Li; Anders Tengholm; Erik Gylfe; Hindrik Mulder; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ATP; Ca2 ; β-cell; α-cell; SERCA; SOCE; muscarinic receptor; insulin secretion; glucagon secretion; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Glucose metabolism in pancreatic α- and β-cells is believed to regulate secretion of glucagon and insulin, respectively. In β-cells, ATP links glucose metabolism to electrical activity and insulin secretion. READ MORE

  7. 5. Physiological changes in mice deficient in different subtypes of thyroid hormone receptors : a focus on studies of heart and muscle

    Author : Catarina Johansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : heart rate; ECG; body temperature; [beta]-adrenergic receptor density; thyroid hormone; isometric twitch; SERCa;

    Abstract : The aim of these studies was to determing the specific roles of the different subtypes of thyroid hormone receptors (TR), with focus on heart and muscle function, by using mice deficient in TR[alpha]1, TR[beta] (both TR[beta]1 and TR[beta]2 subtypes) and TR[alpha]1/[beta]. For this purpose, new techniques were set up to study various physiological parameters in these mice. READ MORE