Search for dissertations about: "sib prevalence"

Found 5 swedish dissertations containing the words sib prevalence.

  2. 1. On Power Estimation and Score Predictions in Affected Sib-Pair Linkage Analysis

    Author : Mikael Knutsson; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; affected sib-pair; linkage analysis; nonparametric linkage score; sib prevalence; statistical genetics; nonparametric linkage score;

    Abstract : This thesis consists of three papers in statistical genetics, with the emphasis on affected sib-pair linkage analysis. In Paper A, a method to derive the power of linkage analysis in genome scans, using a stepwise approach, is presented. READ MORE

  4. 2. Genetic Studies of Alzheimer's Disease

    Author : Elin Blom; Anna Glaser; Martin Ingelsson; Lars Lannfelt; Jan Hillert; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Linkage; Affected sib-pairs; APOE; APP duplication; 10q21; 19q13; Wnt signaling; Geriatrics and medical gerontology; Geriatrik och medicinsk gerontologi;

    Abstract : Patients with Alzheimer's disease (AD) often have a family history of the disease, implicating genetics as a major risk factor. Three genes are currently known to cause familial early-onset AD (65 years), only the APOE gene has repeatedly been associated to AD, where the ε4 allele increases disease risk and decreases age at onset. READ MORE

  5. 3. Gene mapping of atopic dermatitis

    Author : Cilla Söderhäll; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Atopic dermatitis is a hereditary, pruritic, inflammatory and chronic skin disease that typically presents in early childhood. It is often associated with other atopic manifestations, such as asthma, allergic rhinoconjunctivitis, and elevated total and/or allergen-specific serum lgE levels. READ MORE

  6. 4. Aspects of Helicobacter pylori transmission

    Author : Mårten Kivi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Helicobacter pylori; epidemiology; transmission; family; two-stage; missing data; molecular typing; CagA; cag pathogenicity island; variability; microarray;

    Abstract : The bacterium Helicobacter pylori infects the gastric mucosa of about half of the world's population. The infection causes gastritis and contributes to the development of peptic ulcer disease and gastric cancer. H. READ MORE

  7. 5. Genetic mapping and association analysis in multiple sclerosis

    Author : Eva Åkesson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Multiple sclerosis; genetic; linkage; association; susceptibility;

    Abstract : Multiple sclerosis (MS) is a chronic neurological disease. Epidemiological studies have shown evidence for both environmental and genetic involvement of the disease. READ MORE