Search for dissertations about: "sigma receptor"

Showing result 1 - 5 of 7 swedish dissertations containing the words sigma receptor.

  2. 1. Neurosteroids Induce Allosteric Effects on the NMDA Receptor : Nanomolar Concentrations of Neurosteroids Exert Non-Genomic Effects on the NMDA Receptor Complex

    Author : Tobias Johansson; Fred Nyberg; Pierre Le Grevès; Elisabeth Hansson; Uppsala universitet; []
    Keywords : Pharmaceutical pharmacology; Pharmacology; neurosteroids; NMDA receptor; NR2B subunit; ifenprodil; sigma receptor; anabolic androgenic steroids; allosteric modulation; non-genomic; Farmaceutisk farmakologi;

    Abstract : The neurosteroids constitute a group of powerful hormones synthesized and acting in the central nervous system. They participate in a number of important central processes, such as memory and learning, mood and neuroprotection. READ MORE

  4. 2. Characterization of Substance P (SP) Aminoterminal SP (1-7) Binding in Brain Regions and Spinal Cord of the Male Rat : Studies on the Interaction with Opioid Related Pathways

    Author : Milad Botros; Fred Nyberg; Tsukasa Sakurada; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biological research on drug dependence; Biologisk beroendeforskning;

    Abstract : Binding sites for substance P(1-7), SP(1-7) have been identified and characterized for the first time in crude membrane fraction from rat CNS using tritiated ([3H]) SP(1-7) as tracer. These putative receptors were investigated in relation to their affinity for tachykinins, opioid peptides and sigma receptor ligands. READ MORE

  5. 3. Endogenous and treatment-induced neuroplasticity in mouse models of Parkinson's disease

    Author : Francesco Bez; Basala gangliernas patofysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Parkinson´s disease (PD) is an age-related neurodegenerative disorder characterized by a loss of nigral dopamine (DA) neurons that project their axons to the striatum. Striatal DA depletion causes the typical motor symptoms of PD. READ MORE

  6. 4. Neuroplasticity and neurorestoration in the treatment of Parkinson's Disease: Experimental studies in the mouse

    Author : Veronica Francardo; Basala gangliernas patofysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Neuroplasticity is the brain´s capacity to respond to inner and outer challenges with functional and structural reorganizations. An aberrant activation of neuroplasticity pathways may contribute to the development of neurological disease. READ MORE

  7. 5. Impact of candidate genes on obesity and type 2 diabetes

    Author : Ewa-Carin Långberg; Karolinska Institutet; Karolinska Institutet; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Obesity and type 2 diabetes (T2D) have strong genetic components. Identification of susceptibility genes in both diseases will give better knowledge of their pathomechanisms and future therapies. READ MORE