Search for dissertations about: "single-strand break repair"

Showing result 1 - 5 of 6 swedish dissertations containing the words single-strand break repair.

  2. 1. Post-translational modifications in DNA base excision repair : The roles of CK2 and PARP-1

    Author : Cecilia Ström; Thomas Helleday; Hans Krokan; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; base excision repair; single-strand break repair; PARP-1; CK2; XRCC1; mammalian cells; Cell and molecular biology; Cell- och molekylärbiologi; molekylärgenetik; Molecular Genetics;

    Abstract : Base lesions and DNA single-strand breaks (SSBs) are very common types of DNA damage. The base excision repair (BER) and single-strand break repair (SSBR) machineries both require a succession of enzymatic events in order to remove these types of endogenous lesions and to restore the DNA. READ MORE

  4. 2. DNA double-strand break repair in ascomycetes

    Author : Jiang Chen; Stefan Åström; Michael Lisby; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; utvecklingsbiologi; Developmental Biology;

    Abstract : Nonhomologous end joining (NHEJ) and homologous recombination (HR) are two pathways for DNA double strand break (DSB) repair. We found that the NHEJ protein Nej1 interacted physically with the HR protein Srs2, which was dependent on phosphorylation of Nej1 by Dun1. Srs2 recruitment to a DSB partly relied on Nej1 and Dun1. READ MORE

  5. 3. Recognition and signaling of DNA double-strand breaks in human cells

    Author : Ismail Hassan Ismail; Göteborgs universitet; []
    Keywords : DNA-PK; DNA double-strand break; DSB; DNA single-strand break; SSB; DNA damage; ionizing radiation; IR; DNA repair; calicheamicin kappa1; ATM; hydrogen peroxide; H2AX; radiotherapy; radiosensitizer; flow cytometry;

    Abstract : DNA double-strand breaks (DSBs) are the most toxic type of DNA damage. Fortunately, our cells have highly conserved pathways that detect and repair DSBs. Defects in DSB signaling and DSB repair pathways result in genomic instability that predisposes for cancer development. READ MORE

  6. 4. Characterization of Budding Yeast Nonhomologous End-Joining at DNA Double-Strand Breaks and Telomeres

    Author : Sidney Carter; Stefan Åström; Ed Louis; Stockholms universitet; []
    Keywords : DNA repair; nonhomologous end-joining; double-strand break; Developmental Biology; miljömedicinsk utvecklingsbiologi;

    Abstract : The yeast K. lactis efficiently integrates DNA by illegitimate recombination (IR). IR was completely dependent upon nonhomologous end-joining (NHEJ). In contrast to S. READ MORE

  7. 5. Molecular factors relevant to the radiosensitivity of human tumours

    Author : Anya Polischouk; Karolinska Institutet; Karolinska Institutet; []
    Keywords : c-Ha-ras; c-myc; radiosensitivity; DNA double-strand break repair; DNA singlestrand repair;

    Abstract : Oncogenes, activated copies of normal cellular genes, are involved in carcinogenesis and have been suggested to be determinants of cellular radiosensitivity (RS). Mutations and gene rearrangement of c-Ha-RAS and c-MYC oncogenes were analysed in 70 biopsies and 51 blood samples from the same patients and compared with RS estimated by the clinical tumour response and by response to irradiation of tumour samples using subrenal capsule assay. READ MORE