Search for dissertations about: "slow-binding"

Found 2 swedish dissertations containing the word slow-binding.

2. 1. Peptide-Based Inhibitors of Hepatitis C Virus NS3 Serine Protease: Kinetic Aspects and Inhibitor Design

   Author : Anton Poliakov; Helena Danielson; Boris Turk; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; serine protease; inhibitor; slow-binding; protein purification; Biokemi; Biochemistry; Biokemi;

   Abstract : Hepatitis C is a serious disease that affects about 200 million people worldwide. No anti-HCV vaccine or specific anti-viral drugs are available today. Non-structural protein 3 (NS3) of HCV is a bifunctional serine protease/helicase, and the protease has become a prime target in the search for anti-HCV drugs. READ MORE

4. 2. Kinetic Recognition of Nucleic Acids - Studies on the DNA Binding Selectivity of Threading Ruthenium Complexes

   Author : Pär Nordell; Chalmers tekniska högskola; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; intercalation; circular dicroism; ruthenium complexes; sequence selectivity; fluorescence; DNA; supercoiling; spectroscopy; kinetics;

   Abstract : Despite the great progress in our understanding of DNA during the past half-century, there are many important aspects of its chemical and biological role yet to be explored. The principles by which it selectively interacts with other molecules have attracted much interest due to the relevance for fundamental cellular processes, as well as for the development of diagnostic probes and effective pharmaceutical agents. READ MORE