Search for dissertations about: "small scale dosimetry"

Showing result 1 - 5 of 10 swedish dissertations containing the words small scale dosimetry.

2. 1. Small-Scale Dosimetry for the Testis: Applications in Nuclear Medicine Diagnostics and Therapy

   Author : Suaad Meerkhan; Lund Medicinsk strålningsfysik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Testis; 111-In; Autoradiography; Biodistribution; Small-Scale; Monte Carlo; Dosimetry; spermatogonia; gammaH2AX; immunofluorescence;

   Abstract : It is well known that the testicles are among the most radiosensitive tissue, and constitute an important critical target for both external and internal radiation during diagnostic and therapeutic use of radionuclides. In systemic radionuclide therapy where very high activities are administered, the testis may become a dose-limiting organ; often with a complex, non-uniform activity distribution and a resulting non-uniform absorbed-dose distribution. READ MORE

4. 2. Internal dosimetry. Macroscopic, small-scale and microscopic perspectives

   Author : Cecilia Hindorf; Lund Medicinsk strålningsfysik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; radiobiologi; Nukleärmedicin; radiobiology; Nuclear medicine; B-cell lymphoma; Radioimmunotherapy; Radionuclide therapy; Internal dosimetry; Radiopharmaceutical technology; Radiofarmaceutisk teknik;

   Abstract : Internal dosimetry deals with the assessment of absorbed dose for radionuclides distributed inside the body. The absorbed dose is in its turn used for correlation with the biological effect caused by the irradiation. READ MORE

5. 3. Small-Scale Absorbed Dose Modelling in Selective Internal Radiation Therapy : Microsphere Distribution in Normal Liver Tissue

   Author : Jonas Högberg; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; clusters; dosimetry; heterogeneity; liver; microspheres; radioembolisation; simulations; SIRT; surgery; yttrium-90;

   Abstract : Radioembolisation (RE), with yttrium-90 (90Y) labelled microspheres, is an increasingly common treatment method for unresectable liver tumours. The tolerable mean absorbed dose for normal liver (NL) tissue is higher in RE than in External Beam Radiation Therapy (EBRT); absorbed dose heterogeneity is thought to be one important reason, together with a low absorbed dose rate, but the knowledge of microsphere distributions is limited. READ MORE

6. 4. Realistic tissue dosimetry models using Monte Carlo simulations. Applications for radionuclide therapies

   Author : Erik Larsson; Lund Medicinsk strålningsfysik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; internal dosimetry; radionuclide therapy; Monte Carlo; small scale dosimetry;

   Abstract : Radionuclide therapy (RNT) is a generic term for treatment modalities that use a radionuclide labeled to a target-specific molecule. This so-called radiopharmaceutical accumulates in the target, where the ionizing radiation damages the cells. At sufficient levels of radiation, the cells cannot repair themselves. READ MORE

7. 5. Small-scale dosimetry methods for normal tissues after radioembolization and peptide receptor radiotherapies; a focus on the liver parenchyma and the bone marrow

   Author : Jens Hemmingsson; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dosimetry; Radioembolization; PRRT; lutetium-177; terbium-161; yttrium-90;

   Abstract : Radionuclide therapies are increasingly used in cancer treatments as they have been proven to be both effective and safe. As biodistributions and uptake vary widely between patients, a standardized approach is bound to leave a fraction of patients overtreated or undertreated. READ MORE