Search for dissertations about: "soft drug"

Showing result 1 - 5 of 44 swedish dissertations containing the words soft drug.

  2. 1. Approaches to soft drug analogues of dihydrofolate reductase inhibitors : Design and synthesis

    Author : Malin Graffner Nordberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; soft drug; dihydrofolate reductase; synthesis; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; Organic Pharmaceutical Chemistry; Organisk farmaceutisk kemi;

    Abstract : The main objective of the research described in this thesis has been the design and synthesis of inhibitors of the enzyme dihydrofolate reductase (DHFR) intended for local administration and devoid of systemic side-effects. The blocking of the enzymatic activity of DHFR is a key element in the treatment of many diseases, including cancer, bacterial and protozoal infections, and also opportunistic infections associated with AIDS (Pneumocystis carinii pneumonia, PCP). READ MORE

  4. 2. Advancing portable, aqueous drug delivery to the human lung

    Author : Torben Last; Göran Stemme; Niclas Roxhed; Claus-Michael Lehr; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Portable Inhaler; Biopharmaceuticals; Soft-mist inhaler; Transport vesicles; Microfluidic packaging; High-pressure microfluidics; aerosolization; cleanroom-free fabrication; drug delivery; micro-electromechanical systems MEMS ; Applied Medical Technology; Tillämpad medicinsk teknik;

    Abstract : Lung disease profoundly impacts human health: many lung diseases are currently without cure and require continued treatment. Due to their ease of use and integration into the daily routine, portable inhalers are the preferred treatment option for patients. READ MORE

  5. 3. Quantitative 3D reconstruction of porous polymers using FIB-SEM tomography -correlating materials structures to properties of coatings for controlled drug release

    Author : Cecilia Fager; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; tomography; controlled drug release; 3D; connectivity; insulating material; polymer film; soft material; focused ion beam; scanning electron microscopy;

    Abstract : Porous networks are found in a wide range of different advanced and technologically important materials and influence the materials properties. The networks are active components in for example batteries, food and pharmaceuticals. The interconnectivity of a network strongly influences the transport properties. READ MORE

  6. 4. Hydrogels of Poly(vinyl alcohol) and Nanocellulose for Ophthalmic Applications : Synthesis, Characterization, Biocompatibility and Drug Delivery Studies

    Author : Gopi Krishna Tummala; Albert Mihranyan; Natalia Ferraz; Cecilia Persson; Jonas Lindh; Che Connon; Uppsala universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; nanocellulose; poly vinyl alcohol ; hydrogel; cornea regeneration; therapeutic lens; Engineering Science with specialization in Nanotechnology and Functional Materials; Teknisk fysik med inriktning mot nanoteknologi och funktionella material;

    Abstract : Hydrogels are commonly used materials in ophthalmic care as contact lenses, bandage lenses, corneal implants, and cornea regeneration scaffolds. Hydrogels can be produced by physical, chemical, or radiation crosslinking of hydrophilic polymers. READ MORE

  7. 5. Preparation of Tablets from Reservoir Pellets with an Emphasis on the Compression Behaviour and Drug Release

    Author : Åsa Tunón; Göran Alderborn; Michael E. Aulton; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; multiple unit tablets; extrusion-spheronisation; barrier-coating; modified drug release; pellet types; compaction; tablet properties; deformation; densification; Galenisk farmaci; Pharmaceutics; Galenisk farmaci; galenisk farmaci; Pharmaceutics;

    Abstract : The preparation of multiple unit tablets was investigated in this thesis with the intention of gaining a deeper understanding of some of the factors that influence the properties of such tablets.Initially, three different types of pellets (drug, soft and disintegrant pellets) were combined as a model to investigate the ability of the mixture to form disintegrating tablets. READ MORE