Search for dissertations about: "specificity"

Showing result 21 - 25 of 1502 swedish dissertations containing the word specificity.

  2. 21. Novel Methods for Analysis of Heterogeneous Protein-Cell Interactions : Resolving How the Epidermal Growth Factor Binds to Its Receptor

    Author : Hanna Björkelund; Karl Andersson; Lars Gedda; Yosef Yarden; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heterogeneity; Kinetics; EGFR; HER2; LigandTracer; Interaction Map; Internalization; Specificity; Medical Science; Medicinsk vetenskap;

    Abstract : Cells are complex biological units with advanced signalling systems, a dynamic capacity to adapt to its environment, and the ability to divide and grow. In fact, they are of such high level of complexity that it has deemed extremely difficult or even impossible to completely understand cells as complete units. READ MORE

  4. 22. Characterization and Engineering of Protein-Protein Interactions Involving PDZ Domains

    Author : Andreas Karlsson; Per Jemth; Daniel Otzen; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; intrinsically disordered protein regions; PDZ domain; binding kinetics; protein engineering; interaction mechanism; specificity; PDZbody; Chemistry with specialization in Biophysics; Kemi med inriktning mot biofysik;

    Abstract : The work presented in this thesis has contributed with knowledge to several aspects of protein-protein interaction involving PDZ domains. A substantial amount of our proteome contains regions that are intrinsically disordered but fold upon ligand interaction. READ MORE

  5. 23. Clinical Electrocochleography in Menière´s disease

    Author : Kornel Sass; Lund Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intrathoracic pressure; perilymphatic fistula; pressure exposure; endolymphatic hydrops; Menière´s disease; reproducibility; specificity; sensitivity; rarefaction click; condensation click; electrocochleography; summating potential; Otorhinolaryngology; audiology; auditive system and speech; Otorinolaryngologi; audiologi; hörsel- och talorganen;

    Abstract : Electrocochleography (ECoG) is an objective method to evaluate cochlear electrophysiology. The recordings are considered to reflect the mechano-electric processes of the cochlea, and can indicate the presence of suspected endolymphatic hydrops. READ MORE

  6. 24. Acute pancreatitis. With special reference to the activation peptide from carboxypeptidase B (CAPAP) as a predictor of severity

    Author : Stefan Appelros; Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; accuracy; exocrine dysfunction; radioimmunoassay; CAPAP; carboxypeptidase B; activation peptide; aetiology; prediction of severity; morbidity; mortality; severe acute pancreatitis; Incidence; acute pancreatitis; sensitivity; specificity; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

    Abstract : There is a wide range in the reported annual incidence of acute pancreatitis (AP). A minority of these patients develop a severe disease characterised by a high mortality and morbidity. In order to improve the outcome for patients with an attack of severe AP it is important to identify these patients early in the course of disease. READ MORE

  7. 25. Nickel allergy and hand eczema : epidemiological aspects

    Author : Anna Josefson; Birgitta Meding; Bernt Lindelöf; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; childhood eczema; contact allergy; patch test; population-based; predictive value; questionnaire; self-test; sensitivity; specificity; validity; wet work; MEDICINE; MEDICIN; Dermatology and venerology; Dermatologi och venerologi; Dermatology and Venerology; Dermatologi och venereologi;

    Abstract : Nickel allergy is the most prevalent contact allergy and has been discussed as a possible riskfactor for hand eczema. However, hand eczema is one of the most frequently occurring skindiseases and has multifactorial origin. The aim of this thesis was to study the association between nickel allergy and hand eczema in the general population. READ MORE