Search for dissertations about: "statistical in pharmacy"

Showing result 1 - 5 of 24 swedish dissertations containing the words statistical in pharmacy.

  2. 1. Modelling and prediction of drug transport processes with experimental and calculated molecular properties : A multivariate approach

    Author : Thomas Österberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; farmaceutisk farmakologi; Pharmaceutical Pharmacology;

    Abstract : Less than 2% of the lead compounds generated by the pharmaceutical industry enter the exploratory drug-development phase, from which point they stand only a 10% chance of becoming a commercial medicine. A large proportion of the compounds fail due to poor biopharmaceutical properties, such as permeability and solubility. READ MORE

  4. 2. eScience Approaches to Model Selection and Assessment : Applications in Bioinformatics

    Author : Martin Eklund; Jarl Wikberg; Ron Wehrens; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; high-throughout biology; eScience; model selection; model assessment; Bioinformatics; Bioinformatik;

    Abstract : High-throughput experimental methods, such as DNA and protein microarrays, have become ubiquitous and indispensable tools in biology and biomedicine, and the number of high-throughput technologies is constantly increasing. They provide the power to measure thousands of properties of a biological system in a single experiment and have the potential to revolutionize our understanding of biology and medicine. READ MORE

  5. 3. Clinical pharmacy services within a multiprofessional healthcare team

    Author : Lina Hellström; Tommy Eriksson; Göran Petersson; Sven Tågerud; Peter Höglund; Åsa Bondesson; Tommy Westerlund; Linnéuniversitetet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical pharmacy services; pharmacist; medication review; medication reconciliation; medication errors; drug-related problems; inappropriate prescribing; elderly; inpatients; patient readmissions; hospitalisation; multiprofessional; patient care team; continuity of patient care; Klinisk farmaci; farmaceut; läkemedelsgenomgång; läkemedelsavstämning; läkemedelsfel; läkemedelsrelaterade problem; olämpliga läkemedel; äldre; återinläggning; sjukhusinläggning; multiprofessionell; vårdteam; kontinuitet i vården; Biomedical Sciences; Biomedicinsk vetenskap;

    Abstract : Background: The purpose of drug treatment is to reduce morbidity and mortality, and to improve health-related quality of life. However, there are frequent problems associated with drug treatment, especially among the elderly. READ MORE

  6. 4. Pharmacometric Methods and Novel Models for Discrete Data

    Author : Elodie L Plan; Mats O Karlsson; Laura Sargentini-Maier; Armel Stockis; Christian Laveille; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; pharmacodynamics; disease progression; modelling; discrete data; count; ordered categorical; repeated time-to-event; RTTCE; RCEpT; NONMEM; FOCE; LAPLACE; SAEM; AGQ; pain scores; epilepsy seizures; gastroesophageal symptoms; statistical power; simulations; diagnostics; PHARMACY; FARMACI; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Abstract : Pharmacodynamic processes and disease progression are increasingly characterized with pharmacometric models. However, modelling options for discrete-type responses remain limited, although these response variables are commonly encountered clinical endpoints. Types of data defined as discrete data are generally ordinal, e.g. READ MORE

  7. 5. Studies on intrinsic and extrinsic sources of variability in pharmacokinetics and pharmacodynamics

    Author : Johanna Mercke Odeberg; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; toxikologi; pharmacy; pharmacognosy; Pharmacological sciences; Medicin människa och djur ; Medicine human and vertebrates ; genetic polymorphisms UGT1A-and MDR1 gene ; indirect response model; desmopressin; oral lipid based formulations; farmaci; Farmakologi; toxicology; farmakognosi;

    Abstract : Variability in pharmacokinetic and pharmacodynamic parameters between individuals can be due to intrinsic and extrinsic factors. In this thesis three different areas regarding sources of variability have been investigated. 1. Formulation properties as an extrinsic source of variability. READ MORE