Search for dissertations about: "stroke pharmacy"

Showing result 1 - 5 of 8 swedish dissertations containing the words stroke pharmacy.

  2. 1. Use of secondary preventive drugs after stroke

    Author : Maria Sjölander; Eva-Lotta Glader; Rune Dahlqvist; Marie Eriksson; Björn Wettermark; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; stroke; secondary prevention; drug use; equality; medication adherence; medication beliefs; medicin; Medicine; klinisk farmakologi; Clinical Pharmacology; samhällsfarmaci; Social Pharmacy;

    Abstract : Background Stroke is a serious condition that can have significant impact on an individual’s health and is a significant burden on public health and public finances. Secondary preventive drug treatment after stroke is important for decreasing the risk of recurrent strokes. READ MORE

  4. 2. Vascular receptor changes in ischemic stroke

    Author : Emelie Stenman; Lund Medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vascular receptor changes; Ischemic stroke; Endothelin; Angiotensin; Cardiovascular system; Kardiovaskulära systemet; Pharmacological sciences; pharmacognosy; pharmacy; farmakognosi; farmaci; toxikologi; toxicology; Farmakologi;

    Abstract : The present thesis aimed to examine how ischemic stroke affects the vascular endothelin and angiotensin systems in cerebral arteries. To study vascular receptor changes in ischemic stroke transient focal ischemia was induced in rats. READ MORE

  5. 3. Benefits of Pharmacometric Model-Based Design and Analysis of Clinical Trials

    Author : Kristin E Karlsson; E Niclas Jonsson; Mats O Karlsson; Anders Grahnén; Michael K Smith; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; model-based analysis; pharmacometrics; modeling; disease progression; NONMEM; SAEM; Importance sampling; repeated time-to-event; RTTCE; RCEpT; NIH stroke scale; Barthel index; internal validation; external validation; study power; study design; PHARMACY; FARMACI; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Abstract : Quantitative pharmacokinetic-pharmacodynamic and disease progression models are the core of the science of pharmacometrics which has been identified as one of the strategies that can make drug development more effective. To adequately develop and utilize these models one needs to carefully consider the nature of the data, choice of appropriate estimation methods, model evaluation strategies, and, most importantly, the intended use of the model. READ MORE

  6. 4. Models for Ordered Categorical Pharmacodynamic Data

    Author : Per-Henrik Zingmark; Mats O Karlsson; E. Niclas Jonsson; France Mentré; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics Pharmacotherapy; Pharmacodynamic; Modelling; Categorical data; NONMEM; Proportional odds model; Markov model; Differential drug effect model; Farmakokinetik Farmakoterapi; PHARMACY; FARMACI;

    Abstract : In drug development clinical trials are designed to investigate whether a new treatment is safe and has the desired effect on the disease in the target patient population. Categorical endpoints, for example different ranking scales or grading of adverse events, are commonly used to measure effects in the trials. READ MORE

  7. 5. Pharmacoepidemiologic studies on cardiovascular drugs - with special reference to the effectiveness and safety of blood pressure lowering drugs

    Author : Juan Merlo; Malmö Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Farmakologi; toxicology; pharmacy; pharmacognosy; Pharmacological sciences; samhällsmedicin; Socialmedicin; cardiovascular epidemiology; Pharmacoepidemiology; blood pressure; hypertension; cardiovascular drugs; antihypertensive drugs; lipid lowering drugs; nitrates; effectiveness; safety; ecologic studies; Social medicine; cohort studies; farmakognosi; farmaci; toxikologi;

    Abstract : Background: Ischaemic heart disease (IHD) and stroke are the main causes of morbidity and mortality in developed countries and hence constitute a large public health problem. Cardiovascular drugs are used in an effort to prevent (e. g. blood pressure lowering drugs (BPLD) and lipid lowering drugs) and palliate (e. READ MORE