Search for dissertations about: "structure-activity studies"

Showing result 1 - 5 of 80 swedish dissertations containing the words structure-activity studies.

  2. 1. Enzymatic characterization of inhibitors of HIV-1 proteinase : structure-activity and resistance studies

    Author : Ulrika Nillroth; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP;

    Abstract : .... READ MORE

  4. 2. Lysophosphatidic acid : Physiological effects and structure-activity relationships

    Author : Ulrika K. Nilsson; Samuel Svensson; Karin E. Bornfeldt; Linköpings universitet; []
    Keywords : Lysophospholipids pharmacology; physiology; structure-activity relationship; muscle; smooth; drug effects; myometrium; norepinephrine; epinephrine; signal transduction; MEDICINE; MEDICIN;

    Abstract : Lipids havepreviously been considered primarily as building blocks of the cell membrane, but are now also recognized as important cell signaling molecules. Lysophosphatidic acid (LPA) is a glycerophospholipid consisting of a phosphate head group, a linker region, and a lipophilic tail. READ MORE

  5. 3. Internalization mechanisms of cell-penetrating peptides : Structure-activity relationships, cellular distribution and membrane toxicity studies

    Author : Mats Hansen; Ülo Langel; Mark Lindsay; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell-penetrating peptides; mechanisms; toxicity; structure-activity relationship; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Abstract : Transport of substances with pharmaceutical potential over the plasma membrane has been pushed a great step forward with the discovery of short cationic polypeptides, known as cell-penetrating peptides (CPP). Since then, the internalization mechanism and cargo delivery properties of CPPs has been extensively studied. READ MORE

  6. 4. Structure-activity studies of novel colchicine analogs

    Author : Håkan Bladh; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi;

    Abstract : Colchicine, a well-known alkaloid isolated from Colchicum autumnale, interferes with microtubule growth and, therefore affects mitosis and other microtubule dependent functions. We have been interested in the structural requirements of colchicine for tubulin recognition. READ MORE

  7. 5. Bioactive Compounds in the Chemical Defence of Marine Sponges : Structure-Activity Relationships and Pharmacological Targets

    Author : Erik Hedner; Lars Bohlin; Per R Jonsson; Raffaele Riccio; Uppsala universitet; []
    Keywords : Pharmacognosy; 5-hydroxytryptamine; agelasine; agelasimine; antibacterial; antifouling; barettin; bromobenzisoxazolone barettin; cytotoxic; marine; secondary metabolite; sponge; Farmakognosi; Agelas; Geodia barretti;

    Abstract : Marine invertebrates, in particular sponges, represent a source of a wide range of secondary metabolites, many of which have been attributed various defensive capabilities against environmental stress factors. In this thesis sponge-derived low-molecular peptide-like compounds and associated analogs are investigated for bioactivity and pharmacological targets. READ MORE