Search for dissertations about: "subclass antibodies"

Showing result 21 - 25 of 26 swedish dissertations containing the words subclass antibodies.

  2. 21. Complement aberrations and autoantibodies to complement proteins in relation to disease mechanisms

    Author : Lillemor Melander Skattum; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; C3 nephritic factors; GM allotypes; C1q autoantibodies; serum bactericidal activity; Neisseria meningitidis; idiopathic sudden hearing loss; complement; Acute poststreptococcal glomerulonephritis;

    Abstract : The complement system, a part of the innate immune system with several links to the adaptive immune system, plays an important role in the pathogenesis of many diseases. The purpose of this thesis was to document and clarify some of these mechanisms. The thesis is based on four papers (I-IV). READ MORE

  4. 22. Lactobacilli expressing antibody fragments against pathogens

    Author : Anna Hultberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Adherence to mucosal surfaces has been shown to be of great importance in the pathogenesis of various infections in the gastro-intestinal tract. Live recombinant bacteria can be used to deliver active or passive immunity at the mucosal surface, which is the site of entry for the majority of the pathogens. READ MORE

  5. 23. Identification of manifest diabetes and complication development in gestational diabetes mellitus. The pursuit for biomarkers

    Author : Jonatan Dereke; Lund Medicin; []
    Keywords : Gestational diabetes mellitus; Pregnancy; Hyperglycaemia; Biomarkers; Inflammation; Autoantibodies; Prediction;

    Abstract : Gestational diabetes mellitus (GDM) is a type of diabetes which is first recognised during pregnancy. In the county of Skåne in Southern Sweden, over 2% of all pregnancies are complicated by GDM, a number that is generally several times higher worldwide. READ MORE

  6. 24. T cells in atherogenesis

    Author : Anna-Karin L Robertson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : atherosclerosis; T cells; transforming growth factor-beta; CD4; low-density lipoproteins; Th1 Th2; hypercholesterolemia;

    Abstract : The work of this thesis aims to answer the following questions: (1) Which role do CD4+ cells play in atherosclerosis? (2) Is the expression of CD4 essential for the athero-protective effect mediated by immunization with oxidized LDL by adjuvant? (3) How does the antigenspecific T cell response to oxidized LDL influence lesion development? (4) Is there a general shift to Th2 responses in severe hypercholesterolemia? and finally (5) Which role does transforming growth factor-B (TGF-B)-signaling in T cells play in atherogenesis? ApoE-/-CD4-/- mice were used to study the effect of CD4 deficiency in atherosclerosis. The development of atherosclerosis was decreased with attenuated inflammation in apoE-/- mice lacking CD4+ cells compared to immunocompetent apoE-/-. READ MORE

  7. 25. Immune and autoimmune responses to HIV-1 in mucosa and other tissues

    Author : Peter Lundholm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The aim of these studies was to evaluate routes and devices for administration of HIV-1 DNA vaccines. In particular we were interested in mucosal routes for the induction of immunity at mucosal surfaces. We studied the effects of a novel mucosal route, jet-injection, for induction of systemic and local responses. READ MORE